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PEI Fei, WANG Haifeng. Effect of compound bone peptide injection on osteoporotic fractures of thoracolumbar spine, bone density and bone metabolism[J]. Journal of Pharmaceutical Practice and Service, 2021, 39(6): 557-560. doi: 10.12206/j.issn.1006-0111.202101002
Citation: CHEN Yao, SONG Xiangqing. Meropenem regimens based on the simple mathematical model of T>MIC for two-compartment model[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 341-345. doi: 10.3969/j.issn.1006-0111.2017.04.013

Meropenem regimens based on the simple mathematical model of T>MIC for two-compartment model

doi: 10.3969/j.issn.1006-0111.2017.04.013
  • Received Date: 2016-09-17
  • Rev Recd Date: 2017-01-16
  • Objective To simplify the calculation of T>MIC and evaluate meropenem regimens based on the simple mathematical model of T>MIC reported in literature for two-compartment model. Methods Six meropenem regimens were designed according to the recommended dose with the infusion duration of 0.5 h and 3 h. Four different MIC susceptibility breakpoint of meropenem against clinical microbiologic flora were used to formulate different T>MIC.Each T>MIC was calculated by both the simple and two-compartment model of T>MIC.Meropenem regimens were evaluated for different bacterial infections based on the simple model of T>MIC with 40%~100% of the T>MIC% as the target. The t-test suggested no significant difference between the pairs of T>MIC calculated by the two models. Results and Conclusion Simple model of T>MIC can replace the two-compartment model.Meropenem regimens can be optimized based on this simple model of T>MIC conveniently and quickly.
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    [2] Peric M,Browne FA,Jacobs MR,et al.Activity of nine oral agents against gram-positive and gram-negative bacteria encountered in community-acquired infections:Use of pharmacokinetic/pharmacodynamic breakpoints in the comparative assessment of beta-lactam and macrolide antimicrobial agents[J].Clin Ther,2003,25(1):169-177.
    [3] 李小芳,宋香清.哌拉西林他唑巴坦抗铜绿假单胞菌感染的T>MIC%的推导及在方案评价与优化中的作用[J].中国药师,2015,18(7):1086-1091.
    [4] 宋香清,龙明辉,杨立平.基于T>MIC简易数学模型的哌拉西林他唑巴坦给药方案设计与优化[J].中国医院药学杂志,2016,36(11):911-916.
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    [8] Iakovlev SV,Beloborodov VB,Sidorenko SV,et al.Multi-centre study of comparative efficacy of meropenem and combined regimens for empirical antibacterial therapy of severe nosocomial infections:Results of clinical and pharmacoeconomic analysis[J].Antibiot Chemother,2006,51(7):15-27.
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    [11] McKinnon PS,Paladino JA,Schentag JJ.Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections[J].Int J Antimicrob Agents,2008,31(4):345-351.
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    [13] Fraenkel CJ,UllbergM,Bernander S,et al.In vitro activities of three carbapenems against recent bacterial isolates from severely ill patients at Swedish hospitals[J].Scand J Infect Dis,2006,38(10):853-859.
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Meropenem regimens based on the simple mathematical model of T>MIC for two-compartment model

doi: 10.3969/j.issn.1006-0111.2017.04.013

Abstract: Objective To simplify the calculation of T>MIC and evaluate meropenem regimens based on the simple mathematical model of T>MIC reported in literature for two-compartment model. Methods Six meropenem regimens were designed according to the recommended dose with the infusion duration of 0.5 h and 3 h. Four different MIC susceptibility breakpoint of meropenem against clinical microbiologic flora were used to formulate different T>MIC.Each T>MIC was calculated by both the simple and two-compartment model of T>MIC.Meropenem regimens were evaluated for different bacterial infections based on the simple model of T>MIC with 40%~100% of the T>MIC% as the target. The t-test suggested no significant difference between the pairs of T>MIC calculated by the two models. Results and Conclusion Simple model of T>MIC can replace the two-compartment model.Meropenem regimens can be optimized based on this simple model of T>MIC conveniently and quickly.

PEI Fei, WANG Haifeng. Effect of compound bone peptide injection on osteoporotic fractures of thoracolumbar spine, bone density and bone metabolism[J]. Journal of Pharmaceutical Practice and Service, 2021, 39(6): 557-560. doi: 10.12206/j.issn.1006-0111.202101002
Citation: CHEN Yao, SONG Xiangqing. Meropenem regimens based on the simple mathematical model of T>MIC for two-compartment model[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 341-345. doi: 10.3969/j.issn.1006-0111.2017.04.013
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