Progress on pharmacological activities and mechanism of Anemarrhena saponin

LIU Yanping

doi:10.3969/j.issn.1006-0111.2018.01.005

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Volume 36 Issue 1

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2018 > 36(1): 24-29

LIU Yanping. Progress on pharmacological activities and mechanism of Anemarrhena saponin[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 24-29. doi: 10.3969/j.issn.1006-0111.2018.01.005

Citation:

LIU Yanping. Progress on pharmacological activities and mechanism of Anemarrhena saponin[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 24-29. doi: 10.3969/j.issn.1006-0111.2018.01.005

Progress on pharmacological activities and mechanism of Anemarrhena saponin

doi: 10.3969/j.issn.1006-0111.2018.01.005

LIU Yanping

Pudong New Area People's Hospital, Shanghai 201200, China;Shanghai Yangpu Hospital Affiliated to Tongji University, Shanghai 200090, China

Received Date: 2017-06-15
Rev Recd Date: 2017-09-20

Abstract

As a traditional Chinese medicine, Anemarrhena saponin is one of the main components in Anemarrhena. Many pharmacological activities were reported in recent literatures, such as anti-tumor, anti-senile dementia, improving learning and memory, anti-clotting, anti-thrombus, reducing blood glucose and lipid, anti-depression, lowering blood pressure, and so on. In this paper, the pharmacological effects of the Anemarrhena saponin were summarized in four aspects which are anti-tumor, central nervous system, cardiovascular system and endocrine system to provide an important basis for further development of Anemarrhena.
- Anemarrhena saponin,
- pharmacological activity,
- research progress

References

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Progress on pharmacological activities and mechanism of Anemarrhena saponin

Pudong New Area People's Hospital, Shanghai 201200, China;Shanghai Yangpu Hospital Affiliated to Tongji University, Shanghai 200090, China

Received Date: 2017-06-15

Rev Recd Date: 2017-09-20

Key words:

Abstract: As a traditional Chinese medicine, Anemarrhena saponin is one of the main components in Anemarrhena. Many pharmacological activities were reported in recent literatures, such as anti-tumor, anti-senile dementia, improving learning and memory, anti-clotting, anti-thrombus, reducing blood glucose and lipid, anti-depression, lowering blood pressure, and so on. In this paper, the pharmacological effects of the Anemarrhena saponin were summarized in four aspects which are anti-tumor, central nervous system, cardiovascular system and endocrine system to provide an important basis for further development of Anemarrhena.

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Reference (60)

[1]	国家药典委员会. 中华人民共和国药典2015年版(一部)[S]. 北京:中国医药科技出版社,2015.
[2]	王迪,姜艳艳,石任兵. 中药知母质量控制方法研究[J]. 北京中医药大学学报,2011,34(4):263-265.
[3]	孙小明. 知母化学组分特征及其影响因素研究[D]. 北京:北京中医药大学,2008.
[4]	戴骏宇,喻凯,王明奎. 知母皂苷OfficinalisininⅠ对心肌缺血的保护作用及其机制研究[J]. 中药药理与临床,2017,3(3):27-30.
[5]	廖子君,张晓明,郭亚焕,等. 菝葜皂苷元对胃癌BGC-823细胞增殖、凋亡影响的实验研究[J]. 现代肿瘤医学,2010,18(6):1085-1087.
[6]	Ni Y,Gong XG,Lu M.,et al. Mitochondrial ROS burst as an early sign in sarsasapogenin-induced apoptosis in HepG2 cells[J]. Cell Biol Int,2008,32(3):337-343.
[7]	Bao WN,Pan HF,Lu M, et al. The apoptotic effect of sarsasapogenin from Anemarrhena asphodeloides on HepG2 human hepatoma cells[J]. Cell Biol Int,2007,31(9):887-892.
[8]	King FW,Fong S,Griffin C,et al. Timosaponin AⅢ is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress[J]. PLoS ONE,2009,4(9):e72-83.
[9]	Sy LK,Yan SC,Lok CN,et al. Timosaponin A-Ⅲ induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells[J]. Cancer Res,2008,68(24):10229-10237.
[10]	Kang YJ,Chung HJ,Nam JW,et al. Cytotoxic and antineoplastic activity of timosaponin A-Ⅲ for human colon cancer cells[J]. J Nat Prod,2011,74(4):701-706.
[11]	潘会君,莫小辉,冯彦军,等. 知母皂苷AⅢ对人脐静脉内皮细胞增殖和凋亡的影响[J].中国药房,2014,25(43):4049-4051.
[12]	潘会君,陈中建,章丹丹. 知母皂苷AⅢ对2种黑色素瘤细胞生长及巨噬细胞活化的影响[J]. 中国药师,2015,18(2):181-185.
[13]	潘会君,史海霞,陈中建,等. 知母皂苷AⅢ对黑色素瘤B16细胞生长和Bax,Bcl-2 mRNA的影响[J]. 中药新药与临床药理,2015,26(1):48-52.
[14]	Kim KM,Im A,Kim SH,et al. Timosaponin AⅢ inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis[J].Cancer Science,2016,107(2):181-188.
[15]	谭希,潘会君,吴伟达,等. 知母皂苷AⅢ抑制人脑胶质瘤增殖生长的机制研究[J]. 中国中药杂志,2017,42(6):1160-1166.
[16]	潘会君,聂绪强,刘朵,等. 4种中药单体对人胰腺癌PANC-1细胞移植瘤生长的影响及分子机制探讨[J]. 中国中药杂志,2013,38(2):245-248.
[17]	陆文铨,邱彦,庞涛,等. 知母皂苷B-Ⅱ抑制人肺癌细胞A549细胞增殖和迁移的机制研究[J]. 中国药房,2016,27(10):1346-1349.
[18]	胡雅儿,王子玫,张永芳,等. 老年痴呆症药物治疗的一条新途径,知母皂甙元促进脑M受体生成改善记忆功能[J].世界科学技术(中医药现代化),2007,9(2):127-133.
[19]	陈勤,夏宗勤,胡雅儿. 知母皂苷元对痴呆模型大鼠脑内M受体密度分布的影响[J]. 激光生物学报,2003,12(6):445-449.
[20]	陈勤,夏宗勤,胡雅儿. 知母皂苷元对拟痴呆大鼠β-淀粉样肽沉积及胆碱能系统功能的影响[J]. 中国药理学通报,2002,18(4):390-393.
[21]	胡梅,胡雅儿,张蔚,等. 知母活性成分ZMS对老年大鼠脑M受体的调节作用[J]. 中华核医学杂志,2001,21(3):158-161.
[22]	张新战,戴晓莉. 知母皂苷用于老年痴呆大鼠效果观察[J]. 山东医药,2008,48(48):43-44.
[23]	Lee B,Jung K,Kim DH. Timosaponin AⅢ, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice[J]. Pharmacol Biochem Behav,2009,93(2):121-127.
[24]	刘卓,金英,刘婉珠,等. 知母皂苷对脂多糖引起的大鼠学习记忆障碍和炎症反应的影响[J]. 中国药理学通报,2010,26(10):1362-1366.
[25]	刘卓,隋海娟,闫恩志,等. 知母皂苷对脂多糖引起星形胶质细胞炎症因子释放的影响及机制[J]. 中国药理学通报,2012,28(7):970-974.
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Progress on pharmacological activities and mechanism of Anemarrhena saponin

doi: 10.3969/j.issn.1006-0111.2018.01.005

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通讯作者: 陈斌, bchen63@163.com

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