Analysis of flavonoids contents of hops

LI Changhui; XU Yueming; ZHANG Qiaoyan; HAN Ting; XIN Hailiang

doi:10.3969/j.issn.1006-0111.2018.01.013

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Volume 36 Issue 1

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2018 > 36(1): 64-67

BAI Yunjun, ZHAO Yuyang, JIN Yan, FU Lu, YUAN Yuan. Study on leaf epidermal microstructure of medicinal blue herbs[J]. Journal of Pharmaceutical Practice and Service. doi: 10.12206/j.issn.2097-2024.202404069

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LI Changhui, XU Yueming, ZHANG Qiaoyan, HAN Ting, XIN Hailiang. Analysis of flavonoids contents of hops[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 64-67. doi: 10.3969/j.issn.1006-0111.2018.01.013

Analysis of flavonoids contents of hops

doi: 10.3969/j.issn.1006-0111.2018.01.013

1.
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2.
School of Pharmacy, Jiamusi University, Jiamusi 154007, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China
3.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2017-08-14
Rev Recd Date: 2017-10-30

Abstract

Objective To determine the contents of total flavonoids and xanthohumol in hop from 29 different countries and regions. Methods Rutin colorimetric method was used to determine the content of total flavonoids. HPLC-UV method was established for the determination of xanthohumol in hops. HPLC method was performed by Dikma Technologies Diamonsil C₁₈(250 mm×4.6 mm, 5 μm) column with mobile phase acetonitrile-1% glacial acetic acid solution at the flow rate of 1.0 ml/min. The column temperature was 25℃. The detection wavelength was 370 nm. Results The equation of linear regression of total flavonoids was A=30.345C+0.016 8,r=0.999 9. The equation of linear regression of xanthohumol was A=55 446 C+9040.5,r=0.999 9. Their linear ranges were respectively 20.2-404.0 μg/ml, 2.152-43.040 μg/ml, which indicated a good linear relationship. The RSDs of precision and repeatability were less than 2%. The average recoveries of flavonoids and xanthohumol were respectively 102.71% and 100.21%. Conclusion The contents of total flavonoids and xanthohumol in different hops varieties are significantly different and the import hops was better than the domestic hops in this study.
- Humulus lupulus L.,
- total flavonoids,
- xanthohumol

References

[1]	中国科学院中国植物志编辑委员会.中国植物志第二十三卷第一分册[M]. 北京:科学出版社,1998:221.
[2]	徐基平,张霞,刘海英,等. 啤酒花的地理分布与中国的野生啤酒花资源[J]. 干旱区研究,2008,22(1):179-183.
[3]	Zanoli P, Zavatti M. Pharmacognostic and pharmacological profile of Humulus lupulus L[J]. J Ethnopharmacol,2008,116(3):383-396.
[4]	李隽,崔承彬,蔡兵,等. 啤酒花黄酮的研究进展[J]. 中草药, 2008,39(7):1110-1114.
[5]	朱晓建,段开红,张五九,等. 不同种类啤酒花中黄腐酚含量的研究[J]. 食品与发酵工业,2008,34(10):137-140.
[6]	冉生斌. 甘肃省啤酒花产业发展现状、存在问题及发展对策[J]. 浙江农业科学,2013,(11):1532-1535.
[7]	王仿,张霞,刘海英,等. 新疆野生啤酒花总黄酮含量的比较研究[J]. 酿酒科技,2008,(12):27-29.

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Analysis of flavonoids contents of hops

doi: 10.3969/j.issn.1006-0111.2018.01.013

1. School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. School of Pharmacy, Jiamusi University, Jiamusi 154007, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

3. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2017-08-14
Rev Recd Date: 2017-10-30

Key words:

Abstract: Objective To determine the contents of total flavonoids and xanthohumol in hop from 29 different countries and regions. Methods Rutin colorimetric method was used to determine the content of total flavonoids. HPLC-UV method was established for the determination of xanthohumol in hops. HPLC method was performed by Dikma Technologies Diamonsil C₁₈(250 mm×4.6 mm, 5 μm) column with mobile phase acetonitrile-1% glacial acetic acid solution at the flow rate of 1.0 ml/min. The column temperature was 25℃. The detection wavelength was 370 nm. Results The equation of linear regression of total flavonoids was A=30.345C+0.016 8,r=0.999 9. The equation of linear regression of xanthohumol was A=55 446 C+9040.5,r=0.999 9. Their linear ranges were respectively 20.2-404.0 μg/ml, 2.152-43.040 μg/ml, which indicated a good linear relationship. The RSDs of precision and repeatability were less than 2%. The average recoveries of flavonoids and xanthohumol were respectively 102.71% and 100.21%. Conclusion The contents of total flavonoids and xanthohumol in different hops varieties are significantly different and the import hops was better than the domestic hops in this study.

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Analysis of flavonoids contents of hops

doi: 10.3969/j.issn.1006-0111.2018.01.013