Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

CAO Chang, WEN Xiaoli, LIN Wenhua, LI Yang, SHI Tao. Analysis on 2 621 cases of adverse drug reaction reports by Fishbone and Pareto diagram[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 88-92. doi: 10.3969/j.issn.1006-0111.2018.01.019
Citation: CAO Chang, WEN Xiaoli, LIN Wenhua, LI Yang, SHI Tao. Analysis on 2 621 cases of adverse drug reaction reports by Fishbone and Pareto diagram[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 88-92. doi: 10.3969/j.issn.1006-0111.2018.01.019

Analysis on 2 621 cases of adverse drug reaction reports by Fishbone and Pareto diagram

doi: 10.3969/j.issn.1006-0111.2018.01.019
  • Received Date: 2017-09-26
  • Rev Recd Date: 2017-10-30
  • Objective To analyze the regularity and characteristics of 2 621 cases of adverse drug reaction (ADR) occurring in our hospital during 2013-2016, and to explore the factors and causes of ADRs, so as to provide evidence for the continuous improvement of rational use of drugs. Methods 2 621 cases of ADR reports were retrospectively analyzed by monitoring software to extract ADR report source, patient age and sex, related pharmaceutical dosage forms, routes of administration, clinical characterization, organ involvement and other information. The Pareto method was used to identify the main drugs that caused ADR and ADR factorial analysis was performed with Fishbone diagram. Results ADR mainly reported by physicians (2 573 cases, 98.17%) and pharmacists reported at least (3 cases, 0.11%); population aged >70 years accounted for the largest proportion (570 cases, 21.74%); ADR mainly caused by intravenous infusion (1 680 cases, 64.10%). The clinical manifestations were gastrointestinal system lesions(717 cases, 24.17%). Pareto analysis showed that the main drug factors involved anti-infective drugs, anti-neoplastic drugs, Chinese medicine injections and parenteral nutrition drugs. Fishbone analysis showed that elderly patients, intravenous administration, incomplete monitoring and related drugs were the determining factors associated with ARDs. Conclusion The close attention should be paid to monitoring and guidance of special populations, especially the elderly; reducing intravenous forms, monitoring the main factors of medicines, carrying out the individualized medication monitoring, strengthening clinical pharmacy,in order to promote clinical rational use drug and reduce the occurrence of drug-induced diseases.
  • [1] 尼富苓,王霞,田艳平.208例药品不良反应报告分析[J].中国药物应用与监测,2015,12(4):227-230.
    [2] 杨廉平, 练美容, 黄惠明.广东省清远市2008~2010年各年第一季度药品不良反应报告分析[J]. 医药导报2011,30(6):821-823
    [3] 徐萌,郭凤霞,司法启,等.帕累托图分析法在提高我院临床合理用药水平中的应用[J].中国药房2013, 24(5):424-427.
    [4] 刘俊俐, 张贵清, 胡海燕,等. 鱼骨图法应用于肌内注射给药错误的原因分析及对策[J]. 当代护士(中旬刊), 2016,(12):182-184.
    [5] 徐晓华.2012年我院173例药物不良反应报告分析[J].中国实用医药,2014,9(34):11-13.
    [6] 周家梅, 江智霞, 邵星, 等.帕累托图在分级护理质量控制中应用的效果评价[J].中国实用护理杂志, 2013, 29(17):73-74.
    [7] 张菁,吴荣,徐旻. 帕累托图分析法在病房用药安全质量管理中的应用[J].护理研究, 2014, 28(2):232-233.
    [8] 高希花, 张淑丽, 张海燕,等.鱼骨图管理在降低新生儿医源性皮肤损伤中的作用[J].中外医学研究, 2015, 13(6):94-96.
    [9] 孙福珍,张淑玲.老年药品不良反应报告80例分析[J].中国当代医药,2013, 20(3):159-160.
    [10] 朱海静,杨积顺.某三级甲等医院2012-2013年度568例药物不良反应报告分析[J].中国疗养医学, 2014,23(11):1041-1043.
    [11] 张丽心, 田晓红.两例疑似药品不良反应的输液反应分析[J]. 药学服务与研究, 2016,16(2):140,154,157.
    [12] 宋素异,白瑞霞.665例药品不良反应报告回顾性分析[J].中国医院用药评价与分析,2015,15(7):970-971.
    [13] 黄旭慧,蔡加琴,阳丽梅. 临床药师参与口服靶向药物不良反应的管理模式及效果评价[J].中国药学杂志,2015, 50(19):1739-1742.
    [14] 孟蕾, 栾智鹏, 储文功. 基于文献计量的我国医疗机构药品不良反应监测分析.[J]. 药学实践杂志, 2016, 34(3):227-231.
    [15] 王爱军,金永新,要林青.充分发挥临床药师的作用确保肿瘤患者用药安全[J].中国药事,2012,26(2):203-205.
    [16] 徐明琴,陈林,张静霞,等. HPSEC法测定注射用头孢匹胺钠中聚合物的含量[J].国外医药(抗生素分册),2014,35(3):131-133.
    [17] 胥琼. 肿瘤放化疗中的不良反应对策[J].中国医药指南, 2014,12(22):237-238.
    [18] 冯娟,勒毅华,杨瑾,等. 275例抗肿瘤药不良反应分析[J].中国药物与临床,2015,15(8):1186-1188.
    [19] 彭文宣.中药制剂不良反应的监测结果分析和用药管理对策探讨[J].湖南中医药大学学报,2013,33(6):97-98.
    [20] 潘莹,刘韬,梁蔚婷,等.由166例中药不良反应事件/报告分析看中药安全用药[J].中国医院药学杂志,2016,36(2):145-148.
    [21] 秦林飞.中药不良反应原因分析与预防措施[J].中医临床研究,2015,7(35):131-132.
    [22] 刘碧波,蔡国宁,朱建君.251例中药不良反应报告分析[J].中南药学,2007, 5(6):564-566.
    [23] 靳荣.对108份中成药说明书内容的调查与分析[J].中医药管理杂志,2012,20(7):643-644.
    [24] 刘翠丽,田春华,冯红云.医疗机构如何做好药品不良反应监测工作[J].中国药物警戒,2012,9(4):224-226.
    [25] 李旭梅.复方氨基酸注射液致静脉炎反应2例[J].中国药师,2008,11(11):1400.
    [26] 苏庆玲.20AA复方氨基酸注射液不良反应的临床观察及护理措施[J]. 甘肃科技纵横,2015, 44(1):111-112.
    [27] 郦尧旺,陈亚媚,朱光辉.静脉滴注脂肪乳致不良反应70例文献分析[J].中国药业,2010,19(17):58-59.
    [28] 张武标,王晓珉,邵丽丽.127例药物不良反应报告分析[J].临床合理用药杂志,2015,8(26):71-72.
  • 加载中
  • Cited by

    Periodical cited type(33)

    1. 邱蕾. 帕累托图与鱼骨图分析法在基层医院药剂科中成药合理用药中的应用. 中医药管理杂志. 2023(08): 106-109 .
    2. 赵静,韩凤昭. 质量管理工具在人血白蛋白管理中的运用. 中国处方药. 2023(06): 63-66 .
    3. 顾嘉伟. 帕累托图联合鱼骨图分析法在中成药用药改进中的应用. 中医药管理杂志. 2023(15): 102-104 .
    4. 李鑫,张敬一,孙雪. 硝酸酯类药物致不良反应/事件的帕累托分析. 实用药物与临床. 2023(10): 913-917 .
    5. 王馨,陈醒,王兴东,吴波,骆雨璇. 490例药品不良反应报告的临床分析. 医学研究与战创伤救治. 2023(06): 623-627 .
    6. 刘淑仪,丁晓磊. 校园共享电动车出行风险因素及防范研究——以华南A大学为例. 物流工程与管理. 2023(11): 170-173 .
    7. 周杨,任常谕,巫思琼. 2012-2019年我院严重药品不良反应帕累托图分析. 临床合理用药杂志. 2022(01): 164-166 .
    8. 曾贝贝,金超超,余之焕,叶昌兆. 抗肿瘤药物不良反应的Pareto最优分析. 中国社区医师. 2022(09): 3-5 .
    9. 邱永军,汪芳,邱在军. 先兆流产或先兆早产患者初次应用硫酸镁注射液的药品不良反应预测模型研究. 实用临床医药杂志. 2022(09): 63-67 .
    10. 翁国娣,莫家乐,林晓柔. 800张消化内科门诊中成药处方用药合理性与管理建议. 中医药管理杂志. 2022(14): 123-125 .
    11. 罗琪,徐喆,杨欢,汪洋. 先兆流产或先兆早产患者应用硫酸镁注射液的不良反应预测模型. 中国实验诊断学. 2022(08): 1180-1182 .
    12. 潘青杰,张文文,王芳. 羁押人员应用抗感染药物所致的158例不良反应分析. 药学实践杂志. 2021(01): 90-93 .
    13. 袁月玲,张芬,孟晓君,张红梅. 2017-2020年本院368例药物不良反应分析. 中国医学创新. 2021(21): 98-101 .
    14. 刘苑. 帕累托图及鱼骨图分析法在基层医疗机构合理用药管理中的应用. 中国医药指南. 2021(28): 10-12 .
    15. 杨丽雄,蔡丽秋. 某院2019年抗肿瘤药销售金额的帕累托图分析. 海峡药学. 2021(10): 159-161 .
    16. 吕楠,杨帅,田欢,张炜华,吴筱菁,王巧玲,岳宝森. 应用帕累托法分析我院436例药品不良反应报告. 中国医药导刊. 2021(11): 843-847 .
    17. 余玖霞,戎立保. 基于散点图、帕累托图及鱼骨图分析354例药品不良反应情况. 中医临床研究. 2021(36): 142-146 .
    18. 黄莹,刘飞,孔玲娟,赵颉. 质量管理工具对412例药品不良反应报告的分析. 临床合理用药杂志. 2020(03): 165-167 .
    19. 卫峻琦,施芳红,李浩,沈安乐,张顺国. 高风险注射制剂标识方式的帕累托法则分析及标准化研究. 中国药业. 2020(06): 61-63 .
    20. 常渭娟,常便利,陈静. 鱼骨图分析法对乳腺癌患者术后功能锻炼依从性的影响. 临床医学研究与实践. 2020(05): 168-170 .
    21. 吉建,张虹,吕艳艳. 帕累托图及鱼骨图分析法在管理中成药合理用药中的应用. 中国中医药信息杂志. 2020(04): 129-132 .
    22. 吕艳艳,张虹,吉建. 持续改进门诊老年病人镇痛药处方在质量管理中的作用. 安徽医药. 2020(04): 795-799 .
    23. 陈华漫,黄红萍. 药师进行临床督导常见问题的帕累托图-鱼骨图分析. 海峡药学. 2020(05): 231-234 .
    24. 吕天益,匡丽,陈明颖. 1073例热毒宁注射液临床用药帕累托图及鱼骨图分析. 中国药物警戒. 2020(10): 745-748 .
    25. 刘祚汝. PDCA管理模式在规范基层医院中药注射剂使用中的应用研究. 陕西中医药大学学报. 2019(01): 64-68 .
    26. 陈月,鲁戈,孙楚枫,封宇飞. 21468例药物咨询的帕累托图分析. 中国医院用药评价与分析. 2019(02): 246-247+250 .
    27. 王泽洪. PDCA循环在检验科危急值管理中的应用效果. 临床医学研究与实践. 2019(17): 183-184+187 .
    28. 车凤莲,易燕桃,黄小瑜. 我院2016~2018年369例药品不良反应分析. 北方药学. 2019(09): 164-165 .
    29. 韩丽珍. PDCA循环法应用前后肿瘤科病案缺陷状况对比分析. 中国卫生统计. 2019(05): 745-747 .
    30. 曹畅,刘岳金,曾玉兰,钟凯龙,王路敏,曾娜婷,叶岩荣. 我院2018年度门诊不合理抗菌药物处方的帕累托法分析. 中国药物应用与监测. 2019(05): 302-304 .
    31. 童文珍,尹俊英,许俊华,郭霞,郑立新. 鱼骨柏拉图分析法在消毒供应中心医院感染管控中应用的效果. 中华医院感染学杂志. 2019(22): 3506-3510 .
    32. 郭姣丽,覃春英,房子胜,李金桔,樊敏. 我院2013~2018年521例药物不良反应报告分析. 海峡药学. 2019(11): 253-255 .
    33. 程晓珍,夏碧珍. 抗感染药物对肿瘤患者内科治疗的临床效果分析. 中华肿瘤防治杂志. 2019(S1): 145+147 .

    Other cited types(2)

通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(6871) PDF downloads(984) Cited by(35)

Related
Proportional views

Analysis on 2 621 cases of adverse drug reaction reports by Fishbone and Pareto diagram

doi: 10.3969/j.issn.1006-0111.2018.01.019

Abstract: Objective To analyze the regularity and characteristics of 2 621 cases of adverse drug reaction (ADR) occurring in our hospital during 2013-2016, and to explore the factors and causes of ADRs, so as to provide evidence for the continuous improvement of rational use of drugs. Methods 2 621 cases of ADR reports were retrospectively analyzed by monitoring software to extract ADR report source, patient age and sex, related pharmaceutical dosage forms, routes of administration, clinical characterization, organ involvement and other information. The Pareto method was used to identify the main drugs that caused ADR and ADR factorial analysis was performed with Fishbone diagram. Results ADR mainly reported by physicians (2 573 cases, 98.17%) and pharmacists reported at least (3 cases, 0.11%); population aged >70 years accounted for the largest proportion (570 cases, 21.74%); ADR mainly caused by intravenous infusion (1 680 cases, 64.10%). The clinical manifestations were gastrointestinal system lesions(717 cases, 24.17%). Pareto analysis showed that the main drug factors involved anti-infective drugs, anti-neoplastic drugs, Chinese medicine injections and parenteral nutrition drugs. Fishbone analysis showed that elderly patients, intravenous administration, incomplete monitoring and related drugs were the determining factors associated with ARDs. Conclusion The close attention should be paid to monitoring and guidance of special populations, especially the elderly; reducing intravenous forms, monitoring the main factors of medicines, carrying out the individualized medication monitoring, strengthening clinical pharmacy,in order to promote clinical rational use drug and reduce the occurrence of drug-induced diseases.

CAO Chang, WEN Xiaoli, LIN Wenhua, LI Yang, SHI Tao. Analysis on 2 621 cases of adverse drug reaction reports by Fishbone and Pareto diagram[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 88-92. doi: 10.3969/j.issn.1006-0111.2018.01.019
Citation: CAO Chang, WEN Xiaoli, LIN Wenhua, LI Yang, SHI Tao. Analysis on 2 621 cases of adverse drug reaction reports by Fishbone and Pareto diagram[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 88-92. doi: 10.3969/j.issn.1006-0111.2018.01.019
Reference (28)

Catalog

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return