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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(1): 88-92

WANG Chongqing, MA Ningning, YANG Chao, LIU Shihao, ZHU Ju, ZHENG Canhui. Research progress in the catalytic rearrangement reaction of benzyl phenyl ethers[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 486-489. doi: 10.3969/j.issn.1006-0111.2015.06.002
Citation: CAO Chang, WEN Xiaoli, LIN Wenhua, LI Yang, SHI Tao. Analysis on 2 621 cases of adverse drug reaction reports by Fishbone and Pareto diagram[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 88-92. doi: 10.3969/j.issn.1006-0111.2018.01.019
shu

Analysis on 2 621 cases of adverse drug reaction reports by Fishbone and Pareto diagram

doi: 10.3969/j.issn.1006-0111.2018.01.019

  • Department of Pharmacy, Success Hospital Affiliated to Xiamen University, Xiamen, 361005, China

  • Received Date: 2017-09-26
  • Rev Recd Date: 2017-10-30
  • Objective To analyze the regularity and characteristics of 2 621 cases of adverse drug reaction (ADR) occurring in our hospital during 2013-2016, and to explore the factors and causes of ADRs, so as to provide evidence for the continuous improvement of rational use of drugs. Methods 2 621 cases of ADR reports were retrospectively analyzed by monitoring software to extract ADR report source, patient age and sex, related pharmaceutical dosage forms, routes of administration, clinical characterization, organ involvement and other information. The Pareto method was used to identify the main drugs that caused ADR and ADR factorial analysis was performed with Fishbone diagram. Results ADR mainly reported by physicians (2 573 cases, 98.17%) and pharmacists reported at least (3 cases, 0.11%); population aged >70 years accounted for the largest proportion (570 cases, 21.74%); ADR mainly caused by intravenous infusion (1 680 cases, 64.10%). The clinical manifestations were gastrointestinal system lesions(717 cases, 24.17%). Pareto analysis showed that the main drug factors involved anti-infective drugs, anti-neoplastic drugs, Chinese medicine injections and parenteral nutrition drugs. Fishbone analysis showed that elderly patients, intravenous administration, incomplete monitoring and related drugs were the determining factors associated with ARDs. Conclusion The close attention should be paid to monitoring and guidance of special populations, especially the elderly; reducing intravenous forms, monitoring the main factors of medicines, carrying out the individualized medication monitoring, strengthening clinical pharmacy,in order to promote clinical rational use drug and reduce the occurrence of drug-induced diseases.
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Analysis on 2 621 cases of adverse drug reaction reports by Fishbone and Pareto diagram

doi: 10.3969/j.issn.1006-0111.2018.01.019
  • Department of Pharmacy, Success Hospital Affiliated to Xiamen University, Xiamen, 361005, China
  • Received Date: 2017-09-26
  • Rev Recd Date: 2017-10-30

Abstract: Objective To analyze the regularity and characteristics of 2 621 cases of adverse drug reaction (ADR) occurring in our hospital during 2013-2016, and to explore the factors and causes of ADRs, so as to provide evidence for the continuous improvement of rational use of drugs. Methods 2 621 cases of ADR reports were retrospectively analyzed by monitoring software to extract ADR report source, patient age and sex, related pharmaceutical dosage forms, routes of administration, clinical characterization, organ involvement and other information. The Pareto method was used to identify the main drugs that caused ADR and ADR factorial analysis was performed with Fishbone diagram. Results ADR mainly reported by physicians (2 573 cases, 98.17%) and pharmacists reported at least (3 cases, 0.11%); population aged >70 years accounted for the largest proportion (570 cases, 21.74%); ADR mainly caused by intravenous infusion (1 680 cases, 64.10%). The clinical manifestations were gastrointestinal system lesions(717 cases, 24.17%). Pareto analysis showed that the main drug factors involved anti-infective drugs, anti-neoplastic drugs, Chinese medicine injections and parenteral nutrition drugs. Fishbone analysis showed that elderly patients, intravenous administration, incomplete monitoring and related drugs were the determining factors associated with ARDs. Conclusion The close attention should be paid to monitoring and guidance of special populations, especially the elderly; reducing intravenous forms, monitoring the main factors of medicines, carrying out the individualized medication monitoring, strengthening clinical pharmacy,in order to promote clinical rational use drug and reduce the occurrence of drug-induced diseases.

WANG Chongqing, MA Ningning, YANG Chao, LIU Shihao, ZHU Ju, ZHENG Canhui. Research progress in the catalytic rearrangement reaction of benzyl phenyl ethers[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 486-489. doi: 10.3969/j.issn.1006-0111.2015.06.002
Citation: CAO Chang, WEN Xiaoli, LIN Wenhua, LI Yang, SHI Tao. Analysis on 2 621 cases of adverse drug reaction reports by Fishbone and Pareto diagram[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(1): 88-92. doi: 10.3969/j.issn.1006-0111.2018.01.019
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