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Volume 37 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(5): 427-432

LI Chunyan, XU Chen, LU Pengfei, HUANG Baokang. Textual research on the name and reality of edible and medicinal Zisu[J]. Journal of Pharmaceutical Practice and Service, 2023, 41(3): 173-176. doi: 10.12206/j.issn.2097-2024.202112055
Citation: ZENG Qiping, CAI Xiaohui, WU Kunlin, YANG Lina, CAO Yixiang, CHEN Jinshan. Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 427-432. doi: 10.3969/j.issn.1006-0111.2019.05.008
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Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis

doi: 10.3969/j.issn.1006-0111.2019.05.008

  • Department of Pharmacy, No. 909 Hospital of Joint Logistic Support Force/Southeast Hospital Affiliated to Xiamen University, Zhangzhou 363000, China

  • Received Date: 2019-03-15
  • Rev Recd Date: 2019-05-22
  • Objective To investigate the correlation between anti-insomnia effects and HPLC fingerprint of compound caulis polygoni multiflori mixture. Methods A fingerprinting method was established by high performance liquid chromatography and then used to analyze different batches of compound caulis polygoni multiflori mixture.Rat insomnia model was established by intraperitoneal injection of p-chlorophenylalanine,5-HT in rat hippocampus was determined by ELISA.Then the orthogonal partial least squares (OPLS)analysis was used to investigate the spectrum-effect relationship. Results 21 common peaks were identified from the fingerprints,the variable projection importance (VIP)values of these 12 peaks were more than 1.0,indicated that the 3 peaks had played an important role in the anti-insomnia activity of compound caulis polygoni multiflori mixture. Conclusion The anti-insomnia activity of compound caulis polygoni multiflori mixture was the result of synergistic effect of multiple components,its material basis could be analyzed by spectrum-effect relationship,which could provide basis for the quality control of preparation.
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Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis

doi: 10.3969/j.issn.1006-0111.2019.05.008
  • Department of Pharmacy, No. 909 Hospital of Joint Logistic Support Force/Southeast Hospital Affiliated to Xiamen University, Zhangzhou 363000, China
  • Received Date: 2019-03-15
  • Rev Recd Date: 2019-05-22

Abstract: Objective To investigate the correlation between anti-insomnia effects and HPLC fingerprint of compound caulis polygoni multiflori mixture. Methods A fingerprinting method was established by high performance liquid chromatography and then used to analyze different batches of compound caulis polygoni multiflori mixture.Rat insomnia model was established by intraperitoneal injection of p-chlorophenylalanine,5-HT in rat hippocampus was determined by ELISA.Then the orthogonal partial least squares (OPLS)analysis was used to investigate the spectrum-effect relationship. Results 21 common peaks were identified from the fingerprints,the variable projection importance (VIP)values of these 12 peaks were more than 1.0,indicated that the 3 peaks had played an important role in the anti-insomnia activity of compound caulis polygoni multiflori mixture. Conclusion The anti-insomnia activity of compound caulis polygoni multiflori mixture was the result of synergistic effect of multiple components,its material basis could be analyzed by spectrum-effect relationship,which could provide basis for the quality control of preparation.

LI Chunyan, XU Chen, LU Pengfei, HUANG Baokang. Textual research on the name and reality of edible and medicinal Zisu[J]. Journal of Pharmaceutical Practice and Service, 2023, 41(3): 173-176. doi: 10.12206/j.issn.2097-2024.202112055
Citation: ZENG Qiping, CAI Xiaohui, WU Kunlin, YANG Lina, CAO Yixiang, CHEN Jinshan. Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 427-432. doi: 10.3969/j.issn.1006-0111.2019.05.008
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