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Volume 37 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(5): 427-432

ZENG Qiping, CAI Xiaohui, WU Kunlin, YANG Lina, CAO Yixiang, CHEN Jinshan. Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 427-432. doi: 10.3969/j.issn.1006-0111.2019.05.008
Citation: ZENG Qiping, CAI Xiaohui, WU Kunlin, YANG Lina, CAO Yixiang, CHEN Jinshan. Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 427-432. doi: 10.3969/j.issn.1006-0111.2019.05.008
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Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis

doi: 10.3969/j.issn.1006-0111.2019.05.008

  • Department of Pharmacy, No. 909 Hospital of Joint Logistic Support Force/Southeast Hospital Affiliated to Xiamen University, Zhangzhou 363000, China

  • Received Date: 2019-03-15
  • Rev Recd Date: 2019-05-22
  • Objective To investigate the correlation between anti-insomnia effects and HPLC fingerprint of compound caulis polygoni multiflori mixture. Methods A fingerprinting method was established by high performance liquid chromatography and then used to analyze different batches of compound caulis polygoni multiflori mixture.Rat insomnia model was established by intraperitoneal injection of p-chlorophenylalanine,5-HT in rat hippocampus was determined by ELISA.Then the orthogonal partial least squares (OPLS)analysis was used to investigate the spectrum-effect relationship. Results 21 common peaks were identified from the fingerprints,the variable projection importance (VIP)values of these 12 peaks were more than 1.0,indicated that the 3 peaks had played an important role in the anti-insomnia activity of compound caulis polygoni multiflori mixture. Conclusion The anti-insomnia activity of compound caulis polygoni multiflori mixture was the result of synergistic effect of multiple components,its material basis could be analyzed by spectrum-effect relationship,which could provide basis for the quality control of preparation.
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Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis

doi: 10.3969/j.issn.1006-0111.2019.05.008
  • Department of Pharmacy, No. 909 Hospital of Joint Logistic Support Force/Southeast Hospital Affiliated to Xiamen University, Zhangzhou 363000, China
  • Received Date: 2019-03-15
  • Rev Recd Date: 2019-05-22

Abstract: Objective To investigate the correlation between anti-insomnia effects and HPLC fingerprint of compound caulis polygoni multiflori mixture. Methods A fingerprinting method was established by high performance liquid chromatography and then used to analyze different batches of compound caulis polygoni multiflori mixture.Rat insomnia model was established by intraperitoneal injection of p-chlorophenylalanine,5-HT in rat hippocampus was determined by ELISA.Then the orthogonal partial least squares (OPLS)analysis was used to investigate the spectrum-effect relationship. Results 21 common peaks were identified from the fingerprints,the variable projection importance (VIP)values of these 12 peaks were more than 1.0,indicated that the 3 peaks had played an important role in the anti-insomnia activity of compound caulis polygoni multiflori mixture. Conclusion The anti-insomnia activity of compound caulis polygoni multiflori mixture was the result of synergistic effect of multiple components,its material basis could be analyzed by spectrum-effect relationship,which could provide basis for the quality control of preparation.

ZENG Qiping, CAI Xiaohui, WU Kunlin, YANG Lina, CAO Yixiang, CHEN Jinshan. Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 427-432. doi: 10.3969/j.issn.1006-0111.2019.05.008
Citation: ZENG Qiping, CAI Xiaohui, WU Kunlin, YANG Lina, CAO Yixiang, CHEN Jinshan. Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 427-432. doi: 10.3969/j.issn.1006-0111.2019.05.008
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