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Volume 37 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(5): 427-432

ZENG Qiping, CAI Xiaohui, WU Kunlin, YANG Lina, CAO Yixiang, CHEN Jinshan. Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 427-432. doi: 10.3969/j.issn.1006-0111.2019.05.008
Citation: ZENG Qiping, CAI Xiaohui, WU Kunlin, YANG Lina, CAO Yixiang, CHEN Jinshan. Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 427-432. doi: 10.3969/j.issn.1006-0111.2019.05.008
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Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis

doi: 10.3969/j.issn.1006-0111.2019.05.008

  • Department of Pharmacy, No. 909 Hospital of Joint Logistic Support Force/Southeast Hospital Affiliated to Xiamen University, Zhangzhou 363000, China

  • Received Date: 2019-03-15
  • Rev Recd Date: 2019-05-22
  • Objective To investigate the correlation between anti-insomnia effects and HPLC fingerprint of compound caulis polygoni multiflori mixture. Methods A fingerprinting method was established by high performance liquid chromatography and then used to analyze different batches of compound caulis polygoni multiflori mixture.Rat insomnia model was established by intraperitoneal injection of p-chlorophenylalanine,5-HT in rat hippocampus was determined by ELISA.Then the orthogonal partial least squares (OPLS)analysis was used to investigate the spectrum-effect relationship. Results 21 common peaks were identified from the fingerprints,the variable projection importance (VIP)values of these 12 peaks were more than 1.0,indicated that the 3 peaks had played an important role in the anti-insomnia activity of compound caulis polygoni multiflori mixture. Conclusion The anti-insomnia activity of compound caulis polygoni multiflori mixture was the result of synergistic effect of multiple components,its material basis could be analyzed by spectrum-effect relationship,which could provide basis for the quality control of preparation.
  • [1] 王忠,陈寅萤,张盈颖,等.多组分多靶点中药药理作用机制研究中的问题和解决策略[J].中国实验方剂学杂志,2018,24(5):1-6.
    [2] LEE S.Systems biologyA pivotal research methodology for understanding the mechanisms of traditional medicine[J].J Pharmacopunct,2015,18(3):11-18.
    [3] 张雨,李恒,李克宁,等.复方中药网络药理学的研究进展[J].中成药,2018,40(7):1584-1588.
    [4] 刁嘉茵,徐灿,王淑美,等.中药指纹图谱与药效相关性研究进展[J].药学研究,2018,37(3):165-168.
    [5] 蔡靓,张倩,杨丰庆,等.中药谱效学的应用进展[J].中草药,2017,48(23):5005-5011.
    [6] 冯鑫,房德敏,周永梅.谱效关系分析在中药组方研究中的应用进展[J].中国中医基础医学杂志,2018,24(3):422-427.
    [7] 曾棋平,杨丽娜,曹毅祥,等.层次分析联合Box-Behnken效应面法优选复方首乌藤合剂提取工艺[J].中南药学,2017,15(1):48-52.
    [8] 曾棋平,张荣.高效液相色谱法同时测定复方首乌藤合剂中3种成分的含量[J].中南药学,2015,13(8):869-872.
    [9] 杨丽娜,曾棋平,蔡小辉,等.复方首乌藤合剂高效液相指纹图谱研究[J].中南药学,2018,16(1):27-30.
    [10] 池婕,林兵,刘志宏,等.基于最小二乘回归分析法的雷公藤多苷片免疫抑制作用谱效关系研究[J].中草药,2015,46(18):2755-2758.
    [11] 黎理,曾祥燕,谢凤凤,等.竹节蓼药材的HPLC指纹图谱建立及聚类分析[J].中国药房,2018,29(12):1640-1643.
    [12] 卿勇军,刘文,杜平,等.基于灰色关联度分析戊己丸对胃蛋白酶抑制作用的谱效关系[J].中草药,2017,48(16):3390-3395.
    [13] 秦霞,郑华,阮俊翔,等.基于正交投影偏最小二乘法的当归四逆汤谱效关系研究[J].广西医科大学学报,2015,32(3):357-361.
    [14] 肖成荣,马增春,李海静,等.PCPA失眠大鼠模型的制作及其机制[J].毒理学杂志,2007,21(4):326.
    [15] 魏歆然,郑雪娜,裴芸,等.大鼠失眠模型造模中对氯苯丙氨酸混悬液改良法的探讨[J].湖南中医药大学学报,2018,38(9):986-989.
    [16] 王金璐,郭伟英.新益心宁神片镇静催眠作用的谱效关系研究[J].中药材,2017,40(7):1633-1637.
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Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis

doi: 10.3969/j.issn.1006-0111.2019.05.008
  • Department of Pharmacy, No. 909 Hospital of Joint Logistic Support Force/Southeast Hospital Affiliated to Xiamen University, Zhangzhou 363000, China
  • Received Date: 2019-03-15
  • Rev Recd Date: 2019-05-22

Abstract: Objective To investigate the correlation between anti-insomnia effects and HPLC fingerprint of compound caulis polygoni multiflori mixture. Methods A fingerprinting method was established by high performance liquid chromatography and then used to analyze different batches of compound caulis polygoni multiflori mixture.Rat insomnia model was established by intraperitoneal injection of p-chlorophenylalanine,5-HT in rat hippocampus was determined by ELISA.Then the orthogonal partial least squares (OPLS)analysis was used to investigate the spectrum-effect relationship. Results 21 common peaks were identified from the fingerprints,the variable projection importance (VIP)values of these 12 peaks were more than 1.0,indicated that the 3 peaks had played an important role in the anti-insomnia activity of compound caulis polygoni multiflori mixture. Conclusion The anti-insomnia activity of compound caulis polygoni multiflori mixture was the result of synergistic effect of multiple components,its material basis could be analyzed by spectrum-effect relationship,which could provide basis for the quality control of preparation.

ZENG Qiping, CAI Xiaohui, WU Kunlin, YANG Lina, CAO Yixiang, CHEN Jinshan. Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 427-432. doi: 10.3969/j.issn.1006-0111.2019.05.008
Citation: ZENG Qiping, CAI Xiaohui, WU Kunlin, YANG Lina, CAO Yixiang, CHEN Jinshan. Study on spectrum-effect relationship of sedative and hypnotic effect of compound caulis polygoni multiflori mixture based on orthogonal partial least squares regression analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 427-432. doi: 10.3969/j.issn.1006-0111.2019.05.008
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