Advances in research on antimalarial dosage forms

LIU Ping; LU Guangzhao; LU Ying; ZOU Hao

doi:10.3969/j.issn.1006-0111.2019.06.001

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2019 > 37(6): 481-484

LIU Ping, LU Guangzhao, LU Ying, ZOU Hao. Advances in research on antimalarial dosage forms[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 481-484. doi: 10.3969/j.issn.1006-0111.2019.06.001

Citation:

LIU Ping, LU Guangzhao, LU Ying, ZOU Hao. Advances in research on antimalarial dosage forms[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 481-484. doi: 10.3969/j.issn.1006-0111.2019.06.001

Advances in research on antimalarial dosage forms

doi: 10.3969/j.issn.1006-0111.2019.06.001

1.
Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China;Department of Pharmacy, No. 970 hospital of PLA, Yantai 264001, China
2.
Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China

Received Date: 2019-04-08
Rev Recd Date: 2019-10-28

Abstract

Malaria is a critical public health problem resulting in substantial morbidity and mortality in developing countries,especially in Africa.Quinoline,dihydrofolate reductase inhibitors and artemisinin drugs are currently the main drugs for the treatment of malaria,and have good clinical application value,but have the disadvantages of poor solubility,low bioavailability and lack of targeting.To overcome these drawbacks,optimizing the anti-malarial drug dosage form has become a research hotspot at present.Various optimized dosage forms for antimalarial drugs,such as solid dispersions,cyclodextrin inclusion complexes,nanoparticles,liposomes,etc.,are now reviewed.
- malaria,
- antimalarials,
- dosage forms,
- nanoparticles

References

[1]	RAHMAN K,KHAN S U,FAHAD S,et al.Nano-biotechnology:a new approach to treat and prevent malaria[J].Int J Nanomedicine,2019,14:1401-1410.
[2]	SAEED M A,ANSARI M T,CH B A.Enhancement of solubility and dissolution profile of artesunate by employing solid dispersion approach:an in-vitro evaluation[J].Pak J Pharm Sci,2019,32(1):353-361.
[3]	SHAHZAD Y,SOHAIL S,ARSHAD M S,et al.Development of solid dispersions of artemisinin for transdermal delivery[J].Int J Pharm,2013,457(1):197-205.
[4]	LETCHMANAN K,SHEN S C,NG W K,et al.Enhanced dissolution and stability of artemisinin by nano-confinement in ordered mesoporous SBA-15 particles[J].J Microencapsul,2015,32(4):390-400.
[5]	KAKRAN M,SAHOO N G,LI L,et al.Dissolution enhancement of artemisinin with β-cyclodextrin[J].Chem Pharm Bull,2011,59(5):646-652.
[6]	陈方伟,郭涛,李海燕,等.双氢青蒿素羟丙基-β-环糊精包合物的制备与表征[J].药学学报,2012,47(4):529-534.
[7]	KUMAR H,GOTHWAL A,KHAN I,et al.Galactose-anchored gelatin nanoparticles for primaquine delivery and improved pharmacokinetics:a biodegradable and safe approach for effective antiplasmodial activity against P.falciparum 3D7 and in vivo hepatocyte targeting[J].Mol Pharm,2017,14(10):3356-3369.
[8]	DAI H L,GAO W Q,ZHANG G S,et al.Preparation of the nanostructured lipid carriers of artemisinin and its pharmacokinetic evaluation[J].J Chin Pharm,2017,26(3),180-186.
[9]	WANG L,WANG Y F,WANG X Q,et al.Encapsulation of low lipophilic and slightly water-soluble dihydroartemisinin in PLGA nanoparticles with phospholipid to enhance encapsulation efficiency and in vitro bioactivity[J].J Microencapsul,2016,33(1):43-52.
[10]	DAUDA K,BUSARI Z,MORENIKEJI O,et al.Poly(D,L-lactic-co-glycolic acid)-based artesunate nanoparticles:formulation,antimalarial and toxicity assessments[J].J Zhejiang Univ Sci B,2017,18(11):977-985.
[11]	余荧蓝,郑智元,伊宸辰,等.青蒿素长循环脂质体的制备及体外性质评价[J].药学学报,2018,53(6):1002-1008.
[12]	史光玉,王晓蕾,王锐利,等.蒿甲醚纳米结构脂质载体的制备及体外释放[J].中国医药工业杂志,2017,48(5):699-705.
[13]	胡诚,梁琨,安叡,等.TPGS修饰青蒿琥酯脂质体的制备及其体外抗肿瘤活性[J].中成药,2017,39(3):492-498.
[14]	田柳.蒿甲醚脂质体的制备以及其抗肿瘤作用的研究[D].济南:山东大学,2018.
[15]	ISACCHI B,BERGONZI M C,GRAZIOSO M,et al.Artemisinin and artemisinin plus curcumin liposomal formulations:enhanced antimalarial efficacy against Plasmodium berghei-infected mice[J].Eur J Pharm Biopharm,2012,80(3):528-534.
[16]	史光玉.胆碱-聚乙二醇双修饰蒿甲醚脂质纳米粒的制备及其体内外药效与初步靶向性研究[D].太原:山西医科大学,2017.
[17]	柯云玲,潘金明,席建军,等.青蒿琥酯自微乳的制备与质量评价[J].医药导报,2018,37(6):735-740.
[18]	张亚红,唐倩,刘耀,等.自微乳化给药系统提高蒿甲醚大鼠的口服生物利用度[J].第三军医大学学报,2014,36(14):1481-1485.
[19]	席建军,张建康,潘旭旺,等.青蒿琥酯自微乳在大鼠体内的药动学研究[J].中国现代应用药学,2017,34(3):385-389.
[20]	田霞,范云周,孙媛,等.星点设计-效应面法优化蒿甲醚自微乳释药系统[J].国际药学研究杂志,2016,43(5):966-970.
[21]	沈雪松,莫宇玲,金美华,等.青蒿素衍生物微乳系统的研究[J].时珍国医国药,2011,22(4):892-894.
[22]	SAHU S K,RAM A.Preparation and characterization of chloroquine loaded microspheres for prophylactic use[J].Curr Drug Deliv,2013,10(5):601-607.
[23]	潘旭旺,庄让笑,邵益丹,等.青蒿琥酯聚乳酸微球的制备及其药剂学性质研究[J].中华中医药学刊,2014,32(7):1760-1762.
[24]	KHEIRI MANJILI H R,MALVANDI H,MOSAVI M,et al.Preparation and physicochemical characterization of biodegradable mPEG-PCL core-shell micelles for delivery of artemisinin[J].Pharm Sci,2016,22(4):234-243.
[25]	MANJILI H K,MALVANDI H,MOUSAVI M S,et al.In vitro and in vivo delivery of artemisinin loaded PCL-PEG-PCL micelles and its pharmacokinetic study[J].Artif Cells Nanomed Biotechnol,2018,46(5):926-936.
[26]	PESTEHCHIAN N,VAFAEI M R,NEMATOLAHY P,et al.A new effective antiplasmodial compound:nanoformulated pyrimethamine[J].J Glob Antimicrob Resist,2019,19:S2213-S7165.
[27]	邱玉琴,李春,张锁慧,等.蒿甲醚可溶解微针透皮贴片的制备和评价[J].今日药学,2016,26(8):532-537.
[28]	QIU Y Q,LI C,ZHANG S H,et al.Systemic delivery of artemether by dissolving microneedles[J].Int J Pharm,2016,508(1-2):1-9.
[29]	JAIN K,SOOD S,GOWTHAMARAJAN K.Optimization of artemether-loaded NLC for intranasal delivery using central composite design[J].Drug Deliv,2015,22(7):940-954.
[30]	葛斌,徐闫,丁俊威,等.抗疟疾新药研发的各种策略[J].国外医药抗生素分册,2018,39(1):1-13.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Advances in research on antimalarial dosage forms

1. Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China;Department of Pharmacy, No. 970 hospital of PLA, Yantai 264001, China

2. Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China

Received Date: 2019-04-08

Rev Recd Date: 2019-10-28

Key words:

Abstract: Malaria is a critical public health problem resulting in substantial morbidity and mortality in developing countries,especially in Africa.Quinoline,dihydrofolate reductase inhibitors and artemisinin drugs are currently the main drugs for the treatment of malaria,and have good clinical application value,but have the disadvantages of poor solubility,low bioavailability and lack of targeting.To overcome these drawbacks,optimizing the anti-malarial drug dosage form has become a research hotspot at present.Various optimized dosage forms for antimalarial drugs,such as solid dispersions,cyclodextrin inclusion complexes,nanoparticles,liposomes,etc.,are now reviewed.

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Reference (30)

[1]	RAHMAN K,KHAN S U,FAHAD S,et al.Nano-biotechnology:a new approach to treat and prevent malaria[J].Int J Nanomedicine,2019,14:1401-1410.
[2]	SAEED M A,ANSARI M T,CH B A.Enhancement of solubility and dissolution profile of artesunate by employing solid dispersion approach:an in-vitro evaluation[J].Pak J Pharm Sci,2019,32(1):353-361.
[3]	SHAHZAD Y,SOHAIL S,ARSHAD M S,et al.Development of solid dispersions of artemisinin for transdermal delivery[J].Int J Pharm,2013,457(1):197-205.
[4]	LETCHMANAN K,SHEN S C,NG W K,et al.Enhanced dissolution and stability of artemisinin by nano-confinement in ordered mesoporous SBA-15 particles[J].J Microencapsul,2015,32(4):390-400.
[5]	KAKRAN M,SAHOO N G,LI L,et al.Dissolution enhancement of artemisinin with β-cyclodextrin[J].Chem Pharm Bull,2011,59(5):646-652.
[6]	陈方伟,郭涛,李海燕,等.双氢青蒿素羟丙基-β-环糊精包合物的制备与表征[J].药学学报,2012,47(4):529-534.
[7]	KUMAR H,GOTHWAL A,KHAN I,et al.Galactose-anchored gelatin nanoparticles for primaquine delivery and improved pharmacokinetics:a biodegradable and safe approach for effective antiplasmodial activity against P.falciparum 3D7 and in vivo hepatocyte targeting[J].Mol Pharm,2017,14(10):3356-3369.
[8]	DAI H L,GAO W Q,ZHANG G S,et al.Preparation of the nanostructured lipid carriers of artemisinin and its pharmacokinetic evaluation[J].J Chin Pharm,2017,26(3),180-186.
[9]	WANG L,WANG Y F,WANG X Q,et al.Encapsulation of low lipophilic and slightly water-soluble dihydroartemisinin in PLGA nanoparticles with phospholipid to enhance encapsulation efficiency and in vitro bioactivity[J].J Microencapsul,2016,33(1):43-52.
[10]	DAUDA K,BUSARI Z,MORENIKEJI O,et al.Poly(D,L-lactic-co-glycolic acid)-based artesunate nanoparticles:formulation,antimalarial and toxicity assessments[J].J Zhejiang Univ Sci B,2017,18(11):977-985.
[11]	余荧蓝,郑智元,伊宸辰,等.青蒿素长循环脂质体的制备及体外性质评价[J].药学学报,2018,53(6):1002-1008.
[12]	史光玉,王晓蕾,王锐利,等.蒿甲醚纳米结构脂质载体的制备及体外释放[J].中国医药工业杂志,2017,48(5):699-705.
[13]	胡诚,梁琨,安叡,等.TPGS修饰青蒿琥酯脂质体的制备及其体外抗肿瘤活性[J].中成药,2017,39(3):492-498.
[14]	田柳.蒿甲醚脂质体的制备以及其抗肿瘤作用的研究[D].济南:山东大学,2018.
[15]	ISACCHI B,BERGONZI M C,GRAZIOSO M,et al.Artemisinin and artemisinin plus curcumin liposomal formulations:enhanced antimalarial efficacy against Plasmodium berghei-infected mice[J].Eur J Pharm Biopharm,2012,80(3):528-534.
[16]	史光玉.胆碱-聚乙二醇双修饰蒿甲醚脂质纳米粒的制备及其体内外药效与初步靶向性研究[D].太原:山西医科大学,2017.
[17]	柯云玲,潘金明,席建军,等.青蒿琥酯自微乳的制备与质量评价[J].医药导报,2018,37(6):735-740.
[18]	张亚红,唐倩,刘耀,等.自微乳化给药系统提高蒿甲醚大鼠的口服生物利用度[J].第三军医大学学报,2014,36(14):1481-1485.
[19]	席建军,张建康,潘旭旺,等.青蒿琥酯自微乳在大鼠体内的药动学研究[J].中国现代应用药学,2017,34(3):385-389.
[20]	田霞,范云周,孙媛,等.星点设计-效应面法优化蒿甲醚自微乳释药系统[J].国际药学研究杂志,2016,43(5):966-970.
[21]	沈雪松,莫宇玲,金美华,等.青蒿素衍生物微乳系统的研究[J].时珍国医国药,2011,22(4):892-894.
[22]	SAHU S K,RAM A.Preparation and characterization of chloroquine loaded microspheres for prophylactic use[J].Curr Drug Deliv,2013,10(5):601-607.
[23]	潘旭旺,庄让笑,邵益丹,等.青蒿琥酯聚乳酸微球的制备及其药剂学性质研究[J].中华中医药学刊,2014,32(7):1760-1762.
[24]	KHEIRI MANJILI H R,MALVANDI H,MOSAVI M,et al.Preparation and physicochemical characterization of biodegradable mPEG-PCL core-shell micelles for delivery of artemisinin[J].Pharm Sci,2016,22(4):234-243.
[25]	MANJILI H K,MALVANDI H,MOUSAVI M S,et al.In vitro and in vivo delivery of artemisinin loaded PCL-PEG-PCL micelles and its pharmacokinetic study[J].Artif Cells Nanomed Biotechnol,2018,46(5):926-936.
[26]	PESTEHCHIAN N,VAFAEI M R,NEMATOLAHY P,et al.A new effective antiplasmodial compound:nanoformulated pyrimethamine[J].J Glob Antimicrob Resist,2019,19:S2213-S7165.
[27]	邱玉琴,李春,张锁慧,等.蒿甲醚可溶解微针透皮贴片的制备和评价[J].今日药学,2016,26(8):532-537.
[28]	QIU Y Q,LI C,ZHANG S H,et al.Systemic delivery of artemether by dissolving microneedles[J].Int J Pharm,2016,508(1-2):1-9.
[29]	JAIN K,SOOD S,GOWTHAMARAJAN K.Optimization of artemether-loaded NLC for intranasal delivery using central composite design[J].Drug Deliv,2015,22(7):940-954.
[30]	葛斌,徐闫,丁俊威,等.抗疟疾新药研发的各种策略[J].国外医药抗生素分册,2018,39(1):1-13.

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Advances in research on antimalarial dosage forms

doi: 10.3969/j.issn.1006-0111.2019.06.001

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通讯作者: 陈斌, bchen63@163.com

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