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Volume 37 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(6): 559-562

ZHAO Quanfeng, GONG Yuzhu, XIE Gangfeng, XIA Peiyuan, TANG Min. Clinical pharmacists involved in the pharmaceutical care of patients with advanced rectal neuroendocrine tumor[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 559-562. doi: 10.3969/j.issn.1006-0111.2019.06.017
Citation: ZHAO Quanfeng, GONG Yuzhu, XIE Gangfeng, XIA Peiyuan, TANG Min. Clinical pharmacists involved in the pharmaceutical care of patients with advanced rectal neuroendocrine tumor[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 559-562. doi: 10.3969/j.issn.1006-0111.2019.06.017
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Clinical pharmacists involved in the pharmaceutical care of patients with advanced rectal neuroendocrine tumor

doi: 10.3969/j.issn.1006-0111.2019.06.017
  • 1.

    Department of pharmacy, First Affiliated Hospital to Army Medical University, Chongqing 400038, China

  • 2.

    Department of Oncology, Southwest Hospital, First Affiliated Hospital to Army Medical University, Chongqing 400038, China

  • Received Date: 2019-05-08
  • Rev Recd Date: 2019-10-28
  • Objective To investigate the role of clinical pharmacists in anti-tumor therapy in patients with advanced rectal neuroendocrine tumors. Methods Clinical pharmacists participated in the pharmacy service of a patient with advanced rectal neuroendocrine tumor.Combined with the actual situation of the patient,the clinical pharmacist provided advice on the efficacy and safety of the medication and conducted full-course pharmaceutical care. Results Everolimus can cause serious adverse reactions of hyperglycemia and should be monitored when using drugs.Apatinib can be used as a choice for posterior chemotherapy in patients with advanced rectal neuroendocrine tumors. Conclusion In the case of monitoring the adverse effects of new anti-tumor drugs and lack of evidence-based pharmacological evidence,how to choose anti-tumor drugs in the posterior line is the entry point for clinical pharmacists' work,which plays an important role for improving the safety and efficacy of the drug use of patients with advanced rectal neuroendocrine tumors.
  • [1] 徐建明,梁后杰,秦叔逵,等.中国胃肠胰神经内分泌肿瘤专家共识(2016年版)[J].临床肿瘤学杂志,2016,21(10):927-946.
    [2] DASARI A,SHEN C,HALPERIN D,et al.Trends in the incidence,prevalence,and survival outcomes in patients withneuroendocrine tumors in the United States[J].JAMA Oncol,2017,3(10):1335-1342.
    [3] U.S.DEPARTMENT OF HEALTH AND HUMAN SERVICES,Common Terminology Criteria for Adverse Events (CTCAE) v5.0.November 27,2017.
    [4] MORVIDUCCI L,ROTA F,RIZZA L,et al.Everolimus is a new anti-cancer molecule:Metabolic side effects as lipid disorders and hyperglycemia[J].Diabetes Res Clin Pract,2018,143:428-431.
    [5] FAZIO N,BUZZONI R,DELLE FAVE G,et al.Everolimus in advanced,progressive,well-differentiated,non-functional neuroendocrine tumors:RADIANT-4 lung subgroup analysis[J].Cancer Sci,2018,109(1):174-181.
    [6] LIU C T,CHEN M H,CHEN J S,et al.The efficacy and safety of everolimus for the treatment of progressive gastroenteropancreatic neuroendocrine tumors:a multi-institution observational study in Taiwan[J].Asia Pac J Clin Oncol,2016,12(4):396-402.
    [7] GUO Z H,JIAO YY,YI Z M,et al.Increased risk of hyperglycemia associated with the use of everolimus in patients with cancer:a systematic review and Meta-analysis[J].J Chin Pharm Sci,2015,24(5):326-335.
    [8] 依维莫司临床安全性管理专家小组.依维莫司临床安全性管理专家意见[J].中国新药杂志,2014,23(22):2694-2700.
    [9] KUNZ P L,KUO T,ZAHN J M,et al.A phase II study ofcapecitabine,oxaliplatin,and bevacizumab for metastatic or unresectable neuroendocrine tumors[J].J Clin Oncol,2010,28(15_suppl):4104.
    [10] YAO J C,GUTHRIE K A,MORAN C,et al.Phase III prospective randomized comparison trial of depotoctreotide plus interferon Alfa-2b versus depot octreotide plus bevacizumab in patients with advanced carcinoid tumors:SWOG S0518[J].J Clin Oncol,2017,35(15):1695-1703.
    [11] FAIVRE S,NICCOLI P,CASTELLANO D,et al.Sunitinib in pancreatic neuroendocrine tumors:updated progression-free survival and final overall survival from a phase III randomized study[J].Ann Oncol,2017,28(2):339-343.
    [12] CASTELLANO D,CAPDEVILA J,SASTRE J,et al.Sora-fenib and bevacizumab combination targeted therapy in advanced neuroendocrine tumour:a phase II study of Spanish Neuroendocrine Tumour Group (GETNE0801)[J].Eur J Cancer,2013,49(18):3780-3787.
    [13] GRANDE E,CAPDEVILA J,CASTELLANO D,et al.Pazopanib in pretreated advanced neuroendocrine tumors:a phase II,open-label trial of the Spanish task force group for neuroendocrine tumors (GETNE)[J].Ann Oncol,2015,26(9):1987-1993.
    [14] CHEN C,GONG X L,LIAO F,et al.A real world study of efficacy and safety with apatinib therapy in advanced neuroendocrine carcinoma patients[J].J Clin Oncol,2018,36(15_suppl):e14567.
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Clinical pharmacists involved in the pharmaceutical care of patients with advanced rectal neuroendocrine tumor

doi: 10.3969/j.issn.1006-0111.2019.06.017
  • 1. Department of pharmacy, First Affiliated Hospital to Army Medical University, Chongqing 400038, China
  • 2. Department of Oncology, Southwest Hospital, First Affiliated Hospital to Army Medical University, Chongqing 400038, China
  • Received Date: 2019-05-08
  • Rev Recd Date: 2019-10-28

Abstract: Objective To investigate the role of clinical pharmacists in anti-tumor therapy in patients with advanced rectal neuroendocrine tumors. Methods Clinical pharmacists participated in the pharmacy service of a patient with advanced rectal neuroendocrine tumor.Combined with the actual situation of the patient,the clinical pharmacist provided advice on the efficacy and safety of the medication and conducted full-course pharmaceutical care. Results Everolimus can cause serious adverse reactions of hyperglycemia and should be monitored when using drugs.Apatinib can be used as a choice for posterior chemotherapy in patients with advanced rectal neuroendocrine tumors. Conclusion In the case of monitoring the adverse effects of new anti-tumor drugs and lack of evidence-based pharmacological evidence,how to choose anti-tumor drugs in the posterior line is the entry point for clinical pharmacists' work,which plays an important role for improving the safety and efficacy of the drug use of patients with advanced rectal neuroendocrine tumors.

ZHAO Quanfeng, GONG Yuzhu, XIE Gangfeng, XIA Peiyuan, TANG Min. Clinical pharmacists involved in the pharmaceutical care of patients with advanced rectal neuroendocrine tumor[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 559-562. doi: 10.3969/j.issn.1006-0111.2019.06.017
Citation: ZHAO Quanfeng, GONG Yuzhu, XIE Gangfeng, XIA Peiyuan, TANG Min. Clinical pharmacists involved in the pharmaceutical care of patients with advanced rectal neuroendocrine tumor[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 559-562. doi: 10.3969/j.issn.1006-0111.2019.06.017
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