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Volume 13 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 1995  >  (1): 8-12

Wang Rui, Zhao Zhi-jian, Chen Qian, Li Yong, Zhang Yuan-zheng, Tan Ci-e, Pei Bao-xiang, Chen Meng-li. Comparision of bactericidal activity in cerebrospinal fluid of three cephalosporins in the patients undergoing surgery of skull and brain[J]. Journal of Pharmaceutical Practice and Service, 1995, (1): 8-12.
Citation: Wang Rui, Zhao Zhi-jian, Chen Qian, Li Yong, Zhang Yuan-zheng, Tan Ci-e, Pei Bao-xiang, Chen Meng-li. Comparision of bactericidal activity in cerebrospinal fluid of three cephalosporins in the patients undergoing surgery of skull and brain[J]. Journal of Pharmaceutical Practice and Service, 1995, (1): 8-12.
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Comparision of bactericidal activity in cerebrospinal fluid of three cephalosporins in the patients undergoing surgery of skull and brain

  • Chinese PLA General Hospital Dept.Clinical Pharmacology Beijing 100853

  • The bactericidal activity of serum and cerebrospinal fluid(SBA and CBA) of ceftriaxone(CTRX、cefotaxime(CTX))、cefuroxime(CFR)in the patients undergoing surgery of skull and brain were studied by means of microdiluted method.The results showed antibacterial activity of CTRX against Enterobactericeae in vitro or in serum and cerebrospinal fluid(CSF) was the highest,it is suggested that the schadule of lg of CTRX per 12hr may be used in prevention and treatment of serious infections after surgery of skull and brain.The bactericidal activity of CTX against Gram's positive strains and Enterobactericeae in serum and CSF were higher,CTX may be used in infections of nervous system caused by mixed bacteria.The SBA and CBA of CFR were less,but its antibacterial spectrum was wide and the cost was lower,so CFR may be selected in the moderate infections.The CBA was a synthesized guide reflexing the antibactial activity and penetration into barrier,so it is recommanded reference to selected antibiotis infections after surgery of skull and brain.
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Comparision of bactericidal activity in cerebrospinal fluid of three cephalosporins in the patients undergoing surgery of skull and brain

  • Chinese PLA General Hospital Dept.Clinical Pharmacology Beijing 100853

Abstract: The bactericidal activity of serum and cerebrospinal fluid(SBA and CBA) of ceftriaxone(CTRX、cefotaxime(CTX))、cefuroxime(CFR)in the patients undergoing surgery of skull and brain were studied by means of microdiluted method.The results showed antibacterial activity of CTRX against Enterobactericeae in vitro or in serum and cerebrospinal fluid(CSF) was the highest,it is suggested that the schadule of lg of CTRX per 12hr may be used in prevention and treatment of serious infections after surgery of skull and brain.The bactericidal activity of CTX against Gram's positive strains and Enterobactericeae in serum and CSF were higher,CTX may be used in infections of nervous system caused by mixed bacteria.The SBA and CBA of CFR were less,but its antibacterial spectrum was wide and the cost was lower,so CFR may be selected in the moderate infections.The CBA was a synthesized guide reflexing the antibactial activity and penetration into barrier,so it is recommanded reference to selected antibiotis infections after surgery of skull and brain.

Wang Rui, Zhao Zhi-jian, Chen Qian, Li Yong, Zhang Yuan-zheng, Tan Ci-e, Pei Bao-xiang, Chen Meng-li. Comparision of bactericidal activity in cerebrospinal fluid of three cephalosporins in the patients undergoing surgery of skull and brain[J]. Journal of Pharmaceutical Practice and Service, 1995, (1): 8-12.
Citation: Wang Rui, Zhao Zhi-jian, Chen Qian, Li Yong, Zhang Yuan-zheng, Tan Ci-e, Pei Bao-xiang, Chen Meng-li. Comparision of bactericidal activity in cerebrospinal fluid of three cephalosporins in the patients undergoing surgery of skull and brain[J]. Journal of Pharmaceutical Practice and Service, 1995, (1): 8-12.
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