Effect of tetrandrine on 45Ca influx in rat aorta in vitro
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Key words:
- tetrandrine /
- high-K+ /
- phenylephrine /
- 45Ca /
- calcium channel
Abstract: The effects of tetrandrine on calcium influx were studied in rat aorta in vitro.It was found that tetrandrine, similar to verapamil, significantly inhibited high-K+-induced 45Ca influx. But tetrandrine could not inhibit 45Ca influx evoked by phenylephrine, These results suggest that tetrandrine has a specific inhibitary effect on smooth muscle 45Ca influx by inhibiting voltage-operated calcium channel.
Citation: | Tang Zhong-jin, Wang Xiu-ying, Chen Hong, Guan Ying, Zhu Quan-ying, Su Ding-feng. Effect of tetrandrine on 45Ca influx in rat aorta in vitro[J]. Journal of Pharmaceutical Practice and Service, 1995, (2): 72-75. |