Antitumor activity of Chinese Stellese(Stellera chamaejasme L.)

Key words: 
• Chinese Stellera(Stellera chamaejasme L.) /
• antitumor activity /
• S-180

Abstract: Effects of Chinese Stellera(Stellera chamaejsme L. ScL)on the growth of mouse tumor S180 in vivo and in vitro were studied. It wsa found that ScL inhibited the growth of transplanted mouse tumor S180,5-20g/kg(equivalent crude drug)ip for 10d, the inhibition rates of it against S180 were 16.2-47.8%. ScL inhibited the proliferation,MTT formazan formation and clonal formatrion of S-180 celles. The inhibition rate had a positive interrelationship with the concentration and exposure time. These results showed that ScL had an effective antitumor activity in vitro and in vivo.