Studies on bioavailability of nimodipine soft capsules in healthy volunteer
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Key words:
- nimodipine soft capsules /
- bioavailability /
- HPLC method
Abstract: A single oral dose of tablets or soft capsules of 60mg nimodipine was given to 8 healthy volunteers in a randomized crossover study.plasma levels were determined with HPLC method.The plasma concentration-time curve fitted 1-compartment open model,and 2 dose comparative Tmax,Cmax,AUC were not significantly different from that of the tablets(P>0.05).Although the sofe capsules could reach peak level faster,the bioavailability with same biological effect.
Citation: | Cai Changchun, Li Jingsu, Yang Zunxiang, Xie Xiaochan. Studies on bioavailability of nimodipine soft capsules in healthy volunteer[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 288-290. |