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Cai Changchun, Li Jingsu, Yang Zunxiang, Xie Xiaochan. Studies on bioavailability of nimodipine soft capsules in healthy volunteer[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 288-290.
Citation: Cai Changchun, Li Jingsu, Yang Zunxiang, Xie Xiaochan. Studies on bioavailability of nimodipine soft capsules in healthy volunteer[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 288-290.

Studies on bioavailability of nimodipine soft capsules in healthy volunteer

  • A single oral dose of tablets or soft capsules of 60mg nimodipine was given to 8 healthy volunteers in a randomized crossover study.plasma levels were determined with HPLC method.The plasma concentration-time curve fitted 1-compartment open model,and 2 dose comparative Tmax,Cmax,AUC were not significantly different from that of the tablets(P>0.05).Although the sofe capsules could reach peak level faster,the bioavailability with same biological effect.
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Studies on bioavailability of nimodipine soft capsules in healthy volunteer

Abstract: A single oral dose of tablets or soft capsules of 60mg nimodipine was given to 8 healthy volunteers in a randomized crossover study.plasma levels were determined with HPLC method.The plasma concentration-time curve fitted 1-compartment open model,and 2 dose comparative Tmax,Cmax,AUC were not significantly different from that of the tablets(P>0.05).Although the sofe capsules could reach peak level faster,the bioavailability with same biological effect.

Cai Changchun, Li Jingsu, Yang Zunxiang, Xie Xiaochan. Studies on bioavailability of nimodipine soft capsules in healthy volunteer[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 288-290.
Citation: Cai Changchun, Li Jingsu, Yang Zunxiang, Xie Xiaochan. Studies on bioavailability of nimodipine soft capsules in healthy volunteer[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 288-290.

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