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Lin Cai, Dai Qing, Dong Hui, Ma Wenxiu, Liu Songqing. Determination of methadone hydrochloride by HPLC[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 299-301.
Citation: Lin Cai, Dai Qing, Dong Hui, Ma Wenxiu, Liu Songqing. Determination of methadone hydrochloride by HPLC[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 299-301.

Determination of methadone hydrochloride by HPLC

  • To estab1ish a HPLC method for determining methadone hydrochloride and methadone hydrochloride oral solution.Using a Symmetry-C18 Chlumn,a mixture of acetoni trile-monobasic potassium phosphate(pH2.5)(38:62,V/V)as mobile phase and detected at 220nm bupivacaine hydrochloride was used as internal standard.The average recovery was 100.17%.The RSD for the inter inter and intra-day were all less than 1%.The method is simple,rapid and accurate.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of methadone hydrochloride by HPLC

Abstract: To estab1ish a HPLC method for determining methadone hydrochloride and methadone hydrochloride oral solution.Using a Symmetry-C18 Chlumn,a mixture of acetoni trile-monobasic potassium phosphate(pH2.5)(38:62,V/V)as mobile phase and detected at 220nm bupivacaine hydrochloride was used as internal standard.The average recovery was 100.17%.The RSD for the inter inter and intra-day were all less than 1%.The method is simple,rapid and accurate.

Lin Cai, Dai Qing, Dong Hui, Ma Wenxiu, Liu Songqing. Determination of methadone hydrochloride by HPLC[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 299-301.
Citation: Lin Cai, Dai Qing, Dong Hui, Ma Wenxiu, Liu Songqing. Determination of methadone hydrochloride by HPLC[J]. Journal of Pharmaceutical Practice and Service, 1997, (5): 299-301.

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