Studies on teratogenicity of cyclophosphamide in vitro

Key words: 
• cyclophosphamide /
• teratogenicity /
• in vitro

Abstract: Cyclophosphamide is a commonly used antitumor and immunosuppressive drug as well as an important chemical teratogen after exposure in vivo. Methods and models in vitro were effecient in teratogenicity research. In this review, general cousiderations about activation of proteratogen, methods of administation and testing in vitro are introduced. Furthermore, it can be useful for other teratogens studies.