A HPLC method for simultaneous determination of procaine and lidocaine in mixture

Wang Haifeng; Wang Ran; Tang Xiaodong

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Volume 16 Issue 6

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Article Navigation > Journal of Pharmaceutical Practice and Service > 1998 > (6): 355-357

Wang Haifeng, Wang Ran, Tang Xiaodong. A HPLC method for simultaneous determination of procaine and lidocaine in mixture[J]. Journal of Pharmaceutical Practice and Service, 1998, (6): 355-357.

Citation:

Wang Haifeng, Wang Ran, Tang Xiaodong. A HPLC method for simultaneous determination of procaine and lidocaine in mixture[J]. Journal of Pharmaceutical Practice and Service, 1998, (6): 355-357.

A HPLC method for simultaneous determination of procaine and lidocaine in mixture

No. 203 Hospital of PLA, Qiqihaer, 161000

Abstract

Procaine and Lidocaine in mixture were separated and simulboeously assayed by Reverse - phase HPLC, using Nova - pack C18 colum, 3.9 × 150min, a mixture of methyl alcohol, water, butylamine, acetic acide(600:400: 1. 2: 1 v/v) as mobile phase, external standard and 238um detector. The average recovery of 99.76% (RSD = 0.530% ), n = 3 for Lidocaine, 99. 44% (RSD 0.502% ) for procaine. The method is simple, rapid and acurate. The components have good liner relation and respative.
- Reveal-phase HPLC,
- procaine,
- Lidocaine,
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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