Determination of phenacetin and caffeine in compound acetylsalicylic acid tablets by multiple regression spectrophotometry
- Received Date: 1998-07-07
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Key words:
- multiple regression spectrophotometry /
- compound acetylsalicylic acid tablets /
- phenacetin /
- caffeine /
- determination
Abstract: OBJECTIVE To determine phenacetin and caffeine in compound acetylsalicylic acid tablets. METHODS Multiple regression spectrophotometry was adopted as follow:The sample is dissolved in ethanol,add solution of 02mol/L NaOH to hydrolysis acetylsalicylic acid,the components are determined in phosphate salt buffet (pH 6.5). RESULTS The average recoveries for phenacetin and caffeine were 99.8% and 99.9%,with RSD 0.72% and 0.52%,respectively. CONCLUSION Accuracy of the method was compared with official quantitative analysis and no significant difference was found.
Citation: | Fang Hongzhuang, Lei Lili, Liu Xingbao. Determination of phenacetin and caffeine in compound acetylsalicylic acid tablets by multiple regression spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 1999, (1): 31-33. |