Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 17 Issue 2
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 1999  >  (2): 95-96

Wang Yong, Ma Jun. Pharmacokinetics of m-nifedipine in rabbits after intravenous injection[J]. Journal of Pharmaceutical Practice and Service, 1999, (2): 95-96.
Citation: Wang Yong, Ma Jun. Pharmacokinetics of m-nifedipine in rabbits after intravenous injection[J]. Journal of Pharmaceutical Practice and Service, 1999, (2): 95-96.
shu

Pharmacokinetics of m-nifedipine in rabbits after intravenous injection

  • 1.

    Department of Pharmacy, NO.208 Hospital of PLA, Jining 012000

  • 2.

  • Received Date: 1998-08-26
  • OBJECTIVE To study the dose effects on pharmacokinetics of m-Nif. METHODS 15 rabbits were divided into 3 groups receiving iv m-Ni f 05,1,and 2 mg/kg Plasma levels of m-Nif were determined with HPLC method. RESULTS The concentration-time data were fitted with 2-compartment model.The parameters were after iv l mg/kg:Vd=0.37L/kg,Tα/2=6.4min,Tβ/2=84.1min,AUC=94.1mg·min/L,CL=0.65L/(kg·h).No statistically significant diference was found in C1 and Tβ/2 between 3 dose groups.AUC (standardized to body weight)was correlated with doses. CONCLUSION m-Nif was distributed widely and eliminated at a fairly rapid rate in the rabbits.No dose-dependent pharmacokinetics was found after iv m-Nif 0.52mg/kg.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2374) PDF downloads(633) Cited by()

Related
Proportional views

Pharmacokinetics of m-nifedipine in rabbits after intravenous injection

  • 1. Department of Pharmacy, NO.208 Hospital of PLA, Jining 012000
  • 2. 
  • Received Date: 1998-08-26

Abstract: OBJECTIVE To study the dose effects on pharmacokinetics of m-Nif. METHODS 15 rabbits were divided into 3 groups receiving iv m-Ni f 05,1,and 2 mg/kg Plasma levels of m-Nif were determined with HPLC method. RESULTS The concentration-time data were fitted with 2-compartment model.The parameters were after iv l mg/kg:Vd=0.37L/kg,Tα/2=6.4min,Tβ/2=84.1min,AUC=94.1mg·min/L,CL=0.65L/(kg·h).No statistically significant diference was found in C1 and Tβ/2 between 3 dose groups.AUC (standardized to body weight)was correlated with doses. CONCLUSION m-Nif was distributed widely and eliminated at a fairly rapid rate in the rabbits.No dose-dependent pharmacokinetics was found after iv m-Nif 0.52mg/kg.

Wang Yong, Ma Jun. Pharmacokinetics of m-nifedipine in rabbits after intravenous injection[J]. Journal of Pharmaceutical Practice and Service, 1999, (2): 95-96.
Citation: Wang Yong, Ma Jun. Pharmacokinetics of m-nifedipine in rabbits after intravenous injection[J]. Journal of Pharmaceutical Practice and Service, 1999, (2): 95-96.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return