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Volume 17 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 1999  >  (2): 95-96

LIU Li, LONG Ping, YAO Jian-zhong. Determination of luteolin in three kinds of Chrysanthemum morifolium by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 289-290,293.
Citation: Wang Yong, Ma Jun. Pharmacokinetics of m-nifedipine in rabbits after intravenous injection[J]. Journal of Pharmaceutical Practice and Service, 1999, (2): 95-96.
shu

Pharmacokinetics of m-nifedipine in rabbits after intravenous injection

  • 1.

    Department of Pharmacy, NO.208 Hospital of PLA, Jining 012000

  • 2.

  • Received Date: 1998-08-26
  • OBJECTIVE To study the dose effects on pharmacokinetics of m-Nif. METHODS 15 rabbits were divided into 3 groups receiving iv m-Ni f 05,1,and 2 mg/kg Plasma levels of m-Nif were determined with HPLC method. RESULTS The concentration-time data were fitted with 2-compartment model.The parameters were after iv l mg/kg:Vd=0.37L/kg,Tα/2=6.4min,Tβ/2=84.1min,AUC=94.1mg·min/L,CL=0.65L/(kg·h).No statistically significant diference was found in C1 and Tβ/2 between 3 dose groups.AUC (standardized to body weight)was correlated with doses. CONCLUSION m-Nif was distributed widely and eliminated at a fairly rapid rate in the rabbits.No dose-dependent pharmacokinetics was found after iv m-Nif 0.52mg/kg.
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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 11.9 %其他: 11.9 %China: 1.5 %China: 1.5 %[]: 0.2 %[]: 0.2 %上海: 2.7 %上海: 2.7 %北京: 18.2 %北京: 18.2 %南宁: 0.2 %南宁: 0.2 %台州: 0.4 %台州: 0.4 %呼和浩特: 0.2 %呼和浩特: 0.2 %杭州: 0.4 %杭州: 0.4 %深圳: 0.2 %深圳: 0.2 %芒廷维尤: 14.0 %芒廷维尤: 14.0 %西宁: 50.3 %西宁: 50.3 %其他China[]上海北京南宁台州呼和浩特杭州深圳芒廷维尤西宁Highcharts.com
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Pharmacokinetics of m-nifedipine in rabbits after intravenous injection

  • 1. Department of Pharmacy, NO.208 Hospital of PLA, Jining 012000
  • 2. 
  • Received Date: 1998-08-26

Abstract: OBJECTIVE To study the dose effects on pharmacokinetics of m-Nif. METHODS 15 rabbits were divided into 3 groups receiving iv m-Ni f 05,1,and 2 mg/kg Plasma levels of m-Nif were determined with HPLC method. RESULTS The concentration-time data were fitted with 2-compartment model.The parameters were after iv l mg/kg:Vd=0.37L/kg,Tα/2=6.4min,Tβ/2=84.1min,AUC=94.1mg·min/L,CL=0.65L/(kg·h).No statistically significant diference was found in C1 and Tβ/2 between 3 dose groups.AUC (standardized to body weight)was correlated with doses. CONCLUSION m-Nif was distributed widely and eliminated at a fairly rapid rate in the rabbits.No dose-dependent pharmacokinetics was found after iv m-Nif 0.52mg/kg.

LIU Li, LONG Ping, YAO Jian-zhong. Determination of luteolin in three kinds of Chrysanthemum morifolium by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 289-290,293.
Citation: Wang Yong, Ma Jun. Pharmacokinetics of m-nifedipine in rabbits after intravenous injection[J]. Journal of Pharmaceutical Practice and Service, 1999, (2): 95-96.
shu

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