Effects of preconditioning by yixin oral liquid on CEC,plasma ET & CGRP,myocardial pathomorphology of acute myocardial ischemia in rats

Key words: 
• yixin oral liquid /
• preconditioning /
• myocardial ischemia /
• rat

Abstract: OBJECTIVE To investigate the protective effects of preconditioning by yixin oral liquid (YOL) on cardiovascular system of acute myocardial ischemia rats.METHODS Acute myocardial ischemia models in control group,verapamil group and YOL were set up,meanwhile the sham group was built up.Blood would be collected for assaying endothelin (ET) and calcitonin gene-related peptide (CGRP) in plasma,circle endothelial cell (CEG),and myocardial pathomorphological examination would be preceded after the myocardial ischemia models being set up for two hours.RESULTS Both YOL and verapamil could decrease not only the levels of plasma ET (P<0.05) and the amounts of CEC (P<0 01,P<0.05 respectively),but also ameliorate myocardial pathomorphological changes in acute myocardial ischemia rate.The contents of phasma CGRP in verapamil group were lower than those in model group (P<0.05).Difference of the up-mentioned three indexes between YOL group and verapamil group appeared to be insignificant.CONCLUSION Preconditioning by YOL might play an imporatant role in the modulation of plasma ET and CGRP as well as in the amelioration of myocardium and vascular endothelial cells in acute myocardial inchemia rats.