Preparation of ketoprofen gel and experiment on percutaneous absorption in vitro
- Received Date: 1999-03-29
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Key words:
- ketoprofen /
- gel /
- determination /
- percutaneous absorption in vitro
Abstract: OBJECTIVE To avoid the irritation of oral ketoprofen in gastrointestinal tract,the ketoprofen gel was prepared. METHOD Ketoprofen was dispersed in gel base material after it had been dissolved in alcohol and had been neutralized with triethanolamine.And the method of determination,the irritation experiment and the research of absorption in vitro were studied. RESULTS The prescription of ketoprofen gel was rational.The preparation had low irritation and had high effect on percutaneous absorption in vitro. CONCLUSION The preparation could substitute for oral ketoprofen,and the clinic result should be more observed.
Citation: | Fu Ruoqiu, Li Jianping, He Fengci. Preparation of ketoprofen gel and experiment on percutaneous absorption in vitro[J]. Journal of Pharmaceutical Practice and Service, 1999, (5): 288-290. |