Study on the dissolution of mitoxantrone in mitoxantron-hydroxylapatite ceramic composites in vitro
- Received Date: 1999-02-01
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Key words:
- hydroxylapatite ceramic composite /
- wax /
- mitoxantrone /
- rate of drug-releasing
Abstract: OBJECTIVE To investigate the drug-releasing regularity in vitro of variable concentration mitoxantrone,which wax in a matoxantrone hydroxylapatite ceramic composite encapsulated with wax (DHAQ-PHA-WAX) and DHAQ-PHA without the wax.hydroxylapatite ceramic was used as drug carrier and wax as inhibitor. METHODS The released drug concentration per-day was determined by visible spectrometry at λ =660nm. RESULTS There was a significant difference (P<0.05) between DHAQ-PHA dissolution velocity and DHAQ-PHA-WAX. CONCLUTION Releasing of DHAQ could be controlled with DHAQ-PHA-WAX.
Citation: | Jing Li, Zeng Renjie, Sun Weizhang, Liu Qing. Study on the dissolution of mitoxantrone in mitoxantron-hydroxylapatite ceramic composites in vitro[J]. Journal of Pharmaceutical Practice and Service, 1999, (5): 298-299. |