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Volume 18 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2000  >  (1): 19-21

WANG Wen-jian, JIANG Xue-tao, GUO Tao, DONG Zhi-chao. The pharmacokinetics in rabbits of the fluorofur implants made by irradiation-induced polymerization[J]. Journal of Pharmaceutical Practice and Service, 2000, (1): 19-21.
Citation: WANG Wen-jian, JIANG Xue-tao, GUO Tao, DONG Zhi-chao. The pharmacokinetics in rabbits of the fluorofur implants made by irradiation-induced polymerization[J]. Journal of Pharmaceutical Practice and Service, 2000, (1): 19-21.
shu

The pharmacokinetics in rabbits of the fluorofur implants made by irradiation-induced polymerization

  • Received Date: 1999-06-25
  • OBJECTIVE To investigate the in vitro release and the pharmacokinetics in rabbits of the fluorofur implants.METHODS The implant,poly(2-hydroxyelthyl methacrylate)[poly(HEMA)]-collagen composite,made by fluorofur injection. RESULTS The release profiles in vitro conformed to Higuchi kinetics. The release index of the implant was t1/2=9.9h, t0.9=32.7h. The pharmacokinetic parameters in rabbits were:AUC=268.666h·μg/ml,MRT=41.704h,ka=0.334/h. CONCLUSION: The results clearly indicated that the poly(HEMA)-collagen hydrogel made by irradiation-induced polymerization offers excellent potential as a carrier for the sustained release implant of anticancer drugs.
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The pharmacokinetics in rabbits of the fluorofur implants made by irradiation-induced polymerization

  • Received Date: 1999-06-25

Abstract: OBJECTIVE To investigate the in vitro release and the pharmacokinetics in rabbits of the fluorofur implants.METHODS The implant,poly(2-hydroxyelthyl methacrylate)[poly(HEMA)]-collagen composite,made by fluorofur injection. RESULTS The release profiles in vitro conformed to Higuchi kinetics. The release index of the implant was t1/2=9.9h, t0.9=32.7h. The pharmacokinetic parameters in rabbits were:AUC=268.666h·μg/ml,MRT=41.704h,ka=0.334/h. CONCLUSION: The results clearly indicated that the poly(HEMA)-collagen hydrogel made by irradiation-induced polymerization offers excellent potential as a carrier for the sustained release implant of anticancer drugs.

WANG Wen-jian, JIANG Xue-tao, GUO Tao, DONG Zhi-chao. The pharmacokinetics in rabbits of the fluorofur implants made by irradiation-induced polymerization[J]. Journal of Pharmaceutical Practice and Service, 2000, (1): 19-21.
Citation: WANG Wen-jian, JIANG Xue-tao, GUO Tao, DONG Zhi-chao. The pharmacokinetics in rabbits of the fluorofur implants made by irradiation-induced polymerization[J]. Journal of Pharmaceutical Practice and Service, 2000, (1): 19-21.
shu

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