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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2000  >  (3): 154-156

DAI Ye-hua, XU Hong-xiang. Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2000, (3): 154-156.
Citation: DAI Ye-hua, XU Hong-xiang. Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2000, (3): 154-156.
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Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry

  • Received Date: 1999-11-25
  • OBJECTIVE To provide a useful way of quality control,a first order derivative spectrophotometric method had been developed to determine the content and uniformity of content of fenfuramine hydrochloride tables.METHODS Water was selected for solvent.The first derivative spectrum was obtained by scanning from 280 to 220nm.The distance D of the derivative peak at 265nm and valley at 295nm was used as quantitative basis.The assay was calculated by comparing the peak-valley distance of sample with standard.RESULTS There was a good linear relationship between fenfuramine hydrochloride concentration in the range of 0.05～0.40mg/ml and the peak-valley distance of derivative spectrum with r=0.9999.The average recovery form sample was 100.6%. RSD=0.7%(n=6).CONCLUSIONS The proposed method is simple,accurate and reproducible.
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Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry

  • Received Date: 1999-11-25

Abstract: OBJECTIVE To provide a useful way of quality control,a first order derivative spectrophotometric method had been developed to determine the content and uniformity of content of fenfuramine hydrochloride tables.METHODS Water was selected for solvent.The first derivative spectrum was obtained by scanning from 280 to 220nm.The distance D of the derivative peak at 265nm and valley at 295nm was used as quantitative basis.The assay was calculated by comparing the peak-valley distance of sample with standard.RESULTS There was a good linear relationship between fenfuramine hydrochloride concentration in the range of 0.05～0.40mg/ml and the peak-valley distance of derivative spectrum with r=0.9999.The average recovery form sample was 100.6%. RSD=0.7%(n=6).CONCLUSIONS The proposed method is simple,accurate and reproducible.

DAI Ye-hua, XU Hong-xiang. Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2000, (3): 154-156.
Citation: DAI Ye-hua, XU Hong-xiang. Determination of fenfuramine hydrochloride tablets with first order derivative spectrophotometry[J]. Journal of Pharmaceutical Practice and Service, 2000, (3): 154-156.
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