Studies of cytotoxic effect and antitumor effect by Hypericum chinense
- Received Date: 2000-06-27
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Key words:
- Hypericum chinense /
- cytotoxic effect /
- antitumor effect
Abstract: OBJECTIVE To study the cytotoxic effect in vitro and antitumor effect in vivo of Hypericum chinense.METHODS MTT and SRB assay method in vitro and antitumor test in vivo were used.RESULTS The extracts F003、F004、F006 and the compounds hyperlacton C, quercetin, quercitrin show cytotoxic effect on different carcinoma cell in vitro; Under the dose of 20.0mg/(kg·d) × 10d, the inhibitory rates of F003、F004、F005 on S180 in mice were 20.7%、12.4%、31.4 %.CONCLUSION Hypericum chinense show cytotoxic effect in vitro and antitumor effect in viva and should he studied further.
Citation: | XIANG Guang-ya, YANG Yu, RUAN Jin-lan, ZHOU Yi-kai. Studies of cytotoxic effect and antitumor effect by Hypericum chinense[J]. Journal of Pharmaceutical Practice and Service, 2001, (1): 16-18,64. |