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ZHANG Wan-guo, HU Jin-hong, CAI Zhen. Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (2): 78-79.
Citation: ZHANG Wan-guo, HU Jin-hong, CAI Zhen. Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (2): 78-79.

Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat

  • Received Date: 2000-09-03
  • OBJECTIVE To study the hemorheological paramenters in rat with hepatic fibrosis. METHODS Hepatic fibrosis in rat was induced by CCl4 treatment. Whole blood viscosity, plasma viscosity, Hematocrit(Hct) and dynamic parameters of red blood cell(RBC) were investigated. RESULTS As compared with the normal group, the hemorheological parameters such as whole blood viscosity, plasma viscosity, Hematocrit(Hct), RBC's aggregation and rigidity were increased obviously. CONCLUSION High blood vicosity and low RBC's deformation ability can lead to blood circulation obstacle, thus will aggravate hepatic fibrosis.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat

Abstract: OBJECTIVE To study the hemorheological paramenters in rat with hepatic fibrosis. METHODS Hepatic fibrosis in rat was induced by CCl4 treatment. Whole blood viscosity, plasma viscosity, Hematocrit(Hct) and dynamic parameters of red blood cell(RBC) were investigated. RESULTS As compared with the normal group, the hemorheological parameters such as whole blood viscosity, plasma viscosity, Hematocrit(Hct), RBC's aggregation and rigidity were increased obviously. CONCLUSION High blood vicosity and low RBC's deformation ability can lead to blood circulation obstacle, thus will aggravate hepatic fibrosis.

ZHANG Wan-guo, HU Jin-hong, CAI Zhen. Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (2): 78-79.
Citation: ZHANG Wan-guo, HU Jin-hong, CAI Zhen. Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat[J]. Journal of Pharmaceutical Practice and Service, 2001, (2): 78-79.

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