Studies on quality control of dexamethasone liposomes
- Received Date: 2000-07-03
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Key words:
- dexamethasone /
- liposome /
- k-ratio spectrophotometry /
- entrapment efficiency
Abstract: OBJECTIVE To study the main aspects of quality control of dexamethasone liposomes.METHODS The structure of liposomes was studied with negative staining method of TEM.K-ratio spectrophotometry was used to determine the content,and the Macrosep was used to seperate the entrapped from free drugs.RESULTS An excellent linear relationship was obtained with the range of 4~52μg/ml,the average recovery percent was between 98.28%~99.71%.The entrapment efficiency was one of the important parameters of liposomes quality control.It was related with the clinical effect directly,the entrapment efficiency was more than 80%.CONCLUSION This method is accurate,quick and reproducible.
Citation: | ZHENG Yong-hong, QUAN Dong-qin. Studies on quality control of dexamethasone liposomes[J]. Journal of Pharmaceutical Practice and Service, 2001, (2): 86-88. |