Enhancement effect of dipentene in the transdermal absorption of tinidazole
- Received Date: 2000-10-12
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Key words:
- dipentene /
- Azone /
- transdermal enhancer transdermal absorption /
Abstract: OBJECTIVE To study the enhancement effect of dipentene in the transdermal absorption of tinidazole.METHODS In vitro,using side-by-side diffusion cells determines the diffusion of tinidazole across excised mouse skin to compare the enhancement effect of dipentene with Azone at different concentrations in the transdermal absorption of tinidazole.RESULTS Enhancement effects at different concentrations were following 3% dipentene>2% dipentene≈4%Azone>3% Azone.CONCLUSION It is showed that various concentrations of transdermal enhancers could promote absorption of tinidazole in different degrees and 4% Azone and 3% dipentene are the most effective.
Citation: | SHANG Bei-cheng, FANG Li-sha, HE Jian-guo, WEI li-jia, ZHANG song. Enhancement effect of dipentene in the transdermal absorption of tinidazole[J]. Journal of Pharmaceutical Practice and Service, 2001, (2): 89-91. |