Stability of lidocaine hydrochloride injection after alkalinizing
- Received Date: 2000-12-29
-
Key words:
- lidocaine hydrochloride /
- alkalinization /
- stability
Abstract: OBJECTIVE To study the stability of lidocaine hydrochloride after alkalinzing.METHODS Lidocaine hydrochloride injection was diluted 4 kinds of concentration.Each sample was added 5% NaHCO3 with different amounts.The pH and concentration of lidocaine were determined in those special alkaline environment in different time.RESULTS The pH of 4 kinds of alkaline lidocaine were remarkably higher than before with theincrease of 5% NaHCO3.The concentration of lidocaine were remarkably increased by time.But the more 5%NaHCO3 added to,the less the concentration of lidocaine was notability.There was some needle-crystal in the solution after 24 hours.CONCLUSION The best amount of 5% NaHCO3 to add in is between 0.5ml to 2.0ml,and lidocaine hydrochloride injection couldnt put by for long time after alkalized.
Citation: | FANG Qiang-san, MA Yong-de, ZHU Li-qing, SUN Cheng-chun. Stability of lidocaine hydrochloride injection after alkalinizing[J]. Journal of Pharmaceutical Practice and Service, 2001, (3): 151-152,192. |