The enhancement effect of dipentene in the transdermal absorption of ketoconazole
- Received Date: 2001-05-14
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Key words:
- dipentene /
- azone /
- percutaneous absorption /
- transdermal enhancer /
- ketoconazole
Abstract: OBJECTIVE To study the enhancing effect of dipentene in the transdermal absorption of ketoconazol. METHODS The diffusion of ketoconazole acrossed excised mouse skin was determined in vitro using the side-by-side diffusion cells,to compare the enhancement effect of dipentene with azone at difference concentrations in the transdermal absorption of ketoconazole.RESULTS The sequence of enhancements at difference concentrations of dipentene are as follows:3%dipentene> 2%dipentene> 3%azone> 1%dipentene.CONCLUSION It was showed that various concentrations of transdermal enhancers could promote absorption of ketoconazole in different degrees and 3% dipentene was the most effective.
Citation: | SHANG Bei-cheng, XU Gui-li, TANG Bing, FANG Li-sha, LIU Jiang, DUAN Hui-qiong, ZHAO Xing-min. The enhancement effect of dipentene in the transdermal absorption of ketoconazole[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 84-86. |