Improvement of determination of norfloxacin capsules by HPLC
- Received Date: 2001-09-28
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Key words:
- Norfloxacin capsules /
- HPLC /
- determination of content
Abstract: OBJECTIVE Norfloxacin capsules was determined by a improved HPLC method. METHODS The separation was performed on a spherisorb C18 column.The mobile phase was composed of phosphoric acid-triethylamin buf fer-water-acet onitrile(60:30:10).The eluate with a flow rate of 1.0ml·min-1 was detected at the wavelength of 278nm.RESULTS The calibration curves were good linear within the range of 4.8~96μg·ml-1(r=0.99998).The average recovery of norfloxacin was 98.5%,with RSD of 0.5%(n=5).CONCLUSION The improved method is rapid,good repeatabitity,accurate,reliable and suitable for determination of norfloxacin capsules.
Citation: | Li Ming. Improvement of determination of norfloxacin capsules by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 97-99. |