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Volume 20 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2002  >  (2): 99-101

ZHANG Xiu-rong, LIN Tian-mu, WANG Ya-jun, WEI Xu, CHE Jun. Determination of the content of sustained-release ketamine hydrochloride tablets by high-performance liquid chromatography[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 99-101.
Citation: ZHANG Xiu-rong, LIN Tian-mu, WANG Ya-jun, WEI Xu, CHE Jun. Determination of the content of sustained-release ketamine hydrochloride tablets by high-performance liquid chromatography[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 99-101.
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Determination of the content of sustained-release ketamine hydrochloride tablets by high-performance liquid chromatography

  • 1.

    Military Medical College of Jilin, Fourth Military Medical University, Jilin 132013 China

  • 2.

    Jilin Institute for Drug Control, Jilin 132000 China

  • Received Date: 2001-09-24
  • OBJECTIVE To establish a method of the content of sustained release ketamine hydrochloride tablets METHODS HPLC method was used with C18 column as stationary phase and acetonitrile-water(70:30)as mobile phase The detection wavelength was 269nm RESULTS The calibration curve is linear in the range of 31～310μg·ml-1 for ketamine hydrochloride The average recorery was 97.4% with RSD of 0.66%(n=5). CONCLUSION The method is simple,reliable,accurate and can be used for the determ ination of the content of sustained3 release ketamine hydrochloride tablets.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of the content of sustained-release ketamine hydrochloride tablets by high-performance liquid chromatography

  • 1. Military Medical College of Jilin, Fourth Military Medical University, Jilin 132013 China
  • 2. Jilin Institute for Drug Control, Jilin 132000 China
  • Received Date: 2001-09-24

Abstract: OBJECTIVE To establish a method of the content of sustained release ketamine hydrochloride tablets METHODS HPLC method was used with C18 column as stationary phase and acetonitrile-water(70:30)as mobile phase The detection wavelength was 269nm RESULTS The calibration curve is linear in the range of 31～310μg·ml-1 for ketamine hydrochloride The average recorery was 97.4% with RSD of 0.66%(n=5). CONCLUSION The method is simple,reliable,accurate and can be used for the determ ination of the content of sustained3 release ketamine hydrochloride tablets.

ZHANG Xiu-rong, LIN Tian-mu, WANG Ya-jun, WEI Xu, CHE Jun. Determination of the content of sustained-release ketamine hydrochloride tablets by high-performance liquid chromatography[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 99-101.
Citation: ZHANG Xiu-rong, LIN Tian-mu, WANG Ya-jun, WEI Xu, CHE Jun. Determination of the content of sustained-release ketamine hydrochloride tablets by high-performance liquid chromatography[J]. Journal of Pharmaceutical Practice and Service, 2002, (2): 99-101.
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