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WANG Xiao-bo, WANG Jing-guo, XI Rong-gang, ZHANG Zhi-ran. Preparation and stability observation of electron medicinal membrane of roxithromycin[J]. Journal of Pharmaceutical Practice and Service, 2003, (1): 18-20.
Citation: WANG Xiao-bo, WANG Jing-guo, XI Rong-gang, ZHANG Zhi-ran. Preparation and stability observation of electron medicinal membrane of roxithromycin[J]. Journal of Pharmaceutical Practice and Service, 2003, (1): 18-20.

Preparation and stability observation of electron medicinal membrane of roxithromycin

  • Received Date: 2002-08-12
  • OBJECTIVE To prepare electron medicinal membrane of roxithromycin. To develop a method for assay about electron medicinal membrane of roxithromycin and observe its stabilities.METHODS The electron medicinal membrane of roxithromycin was prepared with the electrothermic equipment.The content of roxithromycin was determined by HPLC.The analytical column was YWG-C18 column.The mobile phase was a mixture of acetonitrile methanol 0.5% ammonium acetate(100:80:60), with the detection wavelength at 235 nm. The stabilities of electron medicinal membrane of roxithromycin was studied by determining the changes of roxithromycin contents by HPLC after subjected to high temperature and humidity test.RESULTS The dosage of membrane of roxithromycin is 75mg. Its difference degree of weight is below 10%.Precision and stability were fine. The linear correlation was observed from the concentrations of 0.3 to 1.7mg·ml-1(r=0.9998). The average recovery was 99.23%. Resolution between roxithromycin and other peaks met the requirements. Thermal stabilities of electron medicinal membrane of roxithromycin is good. So is its moist stabilitie. CONCLUSIONS: Stabilities of electron medicinal membrane of roxithromycin is good.The method was convenient, selective and reproducible for assay about electron medicinal membrane of roxithromycin.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Preparation and stability observation of electron medicinal membrane of roxithromycin

Abstract: OBJECTIVE To prepare electron medicinal membrane of roxithromycin. To develop a method for assay about electron medicinal membrane of roxithromycin and observe its stabilities.METHODS The electron medicinal membrane of roxithromycin was prepared with the electrothermic equipment.The content of roxithromycin was determined by HPLC.The analytical column was YWG-C18 column.The mobile phase was a mixture of acetonitrile methanol 0.5% ammonium acetate(100:80:60), with the detection wavelength at 235 nm. The stabilities of electron medicinal membrane of roxithromycin was studied by determining the changes of roxithromycin contents by HPLC after subjected to high temperature and humidity test.RESULTS The dosage of membrane of roxithromycin is 75mg. Its difference degree of weight is below 10%.Precision and stability were fine. The linear correlation was observed from the concentrations of 0.3 to 1.7mg·ml-1(r=0.9998). The average recovery was 99.23%. Resolution between roxithromycin and other peaks met the requirements. Thermal stabilities of electron medicinal membrane of roxithromycin is good. So is its moist stabilitie. CONCLUSIONS: Stabilities of electron medicinal membrane of roxithromycin is good.The method was convenient, selective and reproducible for assay about electron medicinal membrane of roxithromycin.

WANG Xiao-bo, WANG Jing-guo, XI Rong-gang, ZHANG Zhi-ran. Preparation and stability observation of electron medicinal membrane of roxithromycin[J]. Journal of Pharmaceutical Practice and Service, 2003, (1): 18-20.
Citation: WANG Xiao-bo, WANG Jing-guo, XI Rong-gang, ZHANG Zhi-ran. Preparation and stability observation of electron medicinal membrane of roxithromycin[J]. Journal of Pharmaceutical Practice and Service, 2003, (1): 18-20.

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