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TANG Qi-wen, HUANG Hong. Lacrimal pharmacokinetics in rabbit of chloramphenicol eye drops with the addition of densification[J]. Journal of Pharmaceutical Practice and Service, 2003, (5): 277-279.
Citation: TANG Qi-wen, HUANG Hong. Lacrimal pharmacokinetics in rabbit of chloramphenicol eye drops with the addition of densification[J]. Journal of Pharmaceutical Practice and Service, 2003, (5): 277-279.

Lacrimal pharmacokinetics in rabbit of chloramphenicol eye drops with the addition of densification

  • Received Date: 2003-03-29
  • OBJECTIVE :To assess the pharmacokinetic difference after new densifier adding into chloram-phenicol eye drops in rabbits tear. METHODS :The concentration of chloramphenicol in rabbits tear was determined by UV spectrophotometry at different time . The concentration-times data were analyzed with PK-GRAPH. RESULTS: The mean pharmacokinetic parameters of chloramphenicol eye drops in two preparations exhibited significant difference, kinds and concentration of densifier have great effect on pharmacokinetic parameters. CONCLUSION : Chloramphenicol eye drops with the addition of chitosan and sodium hyaluronate as the densifier can slow down decline of drug concentration in tear,may increase significantly the treatment efficacy of the drug.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Lacrimal pharmacokinetics in rabbit of chloramphenicol eye drops with the addition of densification

Abstract: OBJECTIVE :To assess the pharmacokinetic difference after new densifier adding into chloram-phenicol eye drops in rabbits tear. METHODS :The concentration of chloramphenicol in rabbits tear was determined by UV spectrophotometry at different time . The concentration-times data were analyzed with PK-GRAPH. RESULTS: The mean pharmacokinetic parameters of chloramphenicol eye drops in two preparations exhibited significant difference, kinds and concentration of densifier have great effect on pharmacokinetic parameters. CONCLUSION : Chloramphenicol eye drops with the addition of chitosan and sodium hyaluronate as the densifier can slow down decline of drug concentration in tear,may increase significantly the treatment efficacy of the drug.

TANG Qi-wen, HUANG Hong. Lacrimal pharmacokinetics in rabbit of chloramphenicol eye drops with the addition of densification[J]. Journal of Pharmaceutical Practice and Service, 2003, (5): 277-279.
Citation: TANG Qi-wen, HUANG Hong. Lacrimal pharmacokinetics in rabbit of chloramphenicol eye drops with the addition of densification[J]. Journal of Pharmaceutical Practice and Service, 2003, (5): 277-279.

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