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Volume 22 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2004  >  (4): 200-202

LIU Zhi-xian, LI Fan-zhu, CHEN Jian-ming, FANG Jian-wen. Study on permeation profile of 125I-α-cobratoxin across nasal mucosa and the enhancement of borneol[J]. Journal of Pharmaceutical Practice and Service, 2004, (4): 200-202.
Citation: LIU Zhi-xian, LI Fan-zhu, CHEN Jian-ming, FANG Jian-wen. Study on permeation profile of 125I-α-cobratoxin across nasal mucosa and the enhancement of borneol[J]. Journal of Pharmaceutical Practice and Service, 2004, (4): 200-202.
shu

Study on permeation profile of 125I-α-cobratoxin across nasal mucosa and the enhancement of borneol

  • 1.

    Department of Pharmacy, Shenyang Bone Hospital, Shenyang 110044, China

  • 2.

    Department of Pharmacy, Zhejiang College of TCM, Hangzhou 310053, China

  • 3.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2004-05-10
  • Objective To determine the permeation profile of 125I-α-cobratoxin across different animals'nasal mucosa and the enhancement of borneol. Methods The rabbits、dogs and goats was selected as model animals, radioactivity (count per minute, cpm)as index, and a method called permeation of nasal mucosa in vitro was adopted,together with repeated cycle technique in situ to compare the permeation profile of Nt across different animals'nasal mucosa in vitro in order to confirm the permeation of these animals and the effect of borneol. Results Nt could penetrate the nasal mucosa of different animals and be absorbed, but the amount was low. However, the absorption could be enhanced under the help of borneol. Conclusion Borneol could enhance the absorption of Nt arcoss the nasal mucosa.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Study on permeation profile of 125I-α-cobratoxin across nasal mucosa and the enhancement of borneol

  • 1. Department of Pharmacy, Shenyang Bone Hospital, Shenyang 110044, China
  • 2. Department of Pharmacy, Zhejiang College of TCM, Hangzhou 310053, China
  • 3. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2004-05-10

Abstract: Objective To determine the permeation profile of 125I-α-cobratoxin across different animals'nasal mucosa and the enhancement of borneol. Methods The rabbits、dogs and goats was selected as model animals, radioactivity (count per minute, cpm)as index, and a method called permeation of nasal mucosa in vitro was adopted,together with repeated cycle technique in situ to compare the permeation profile of Nt across different animals'nasal mucosa in vitro in order to confirm the permeation of these animals and the effect of borneol. Results Nt could penetrate the nasal mucosa of different animals and be absorbed, but the amount was low. However, the absorption could be enhanced under the help of borneol. Conclusion Borneol could enhance the absorption of Nt arcoss the nasal mucosa.

LIU Zhi-xian, LI Fan-zhu, CHEN Jian-ming, FANG Jian-wen. Study on permeation profile of 125I-α-cobratoxin across nasal mucosa and the enhancement of borneol[J]. Journal of Pharmaceutical Practice and Service, 2004, (4): 200-202.
Citation: LIU Zhi-xian, LI Fan-zhu, CHEN Jian-ming, FANG Jian-wen. Study on permeation profile of 125I-α-cobratoxin across nasal mucosa and the enhancement of borneol[J]. Journal of Pharmaceutical Practice and Service, 2004, (4): 200-202.
shu

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