Relative bioavailability of cefixime tablets and capsules in human subjects

Key words: 
• relative bioavailability /
• HPLC /
• cefixime /
• capsules/tablets /
• cefspan

Abstract: Objective To compare the bioavailability of cefixime tablets and capsules with Cefspan's (marketed cefixime capsules) in human subjects. Methods A reversed-phase high performance liquid chromatography was used for the determination of cefixime in plasma after a single oral dose of 400mg cefixime tablets,capsules and cefspan in a crossover design. Results The pharmaco-kinetic parameters of cefixime tablets, capsules and cefspan are as follows: AUC_0→1(27.29±8.76)μg/mL·h,(28.12±8.91)μg/mL·h and(27.76±8.25)μg/mL·h,AUC_0→∞(28.12±9.11)μg/mL·h,(28.98 ±9.33)μg/mL·h and(28.72±8.78)μg/mL·h,t_max(4.00±0.36)h,(4.00±0.35)h and (4.00±0.37)h.C_max(4.75±1.21)μg/mL,(4.76±1.05)μg/mL and(4.75 ±1.10)μg/mL,t_1/2(2.70±0.38)h, (2.65±0.57)h and (2.78±0.61)h, MRT_0-T(5.52±0.60)h, (5.57±0.59)h and (5.54±0.57)h. Conclusion The cefixime capsules and tablets are bioequivalent with Cefspan.