Determination of the adefovir dipivoxil raw material by nonaqueous acid-base e-lectrolytic titrations

Key words: 
• nonaqueous acid-base electrolytic titrations /
• content /
• adefovir dipivoxil

Abstract: Objective To establish nonaqueous acicle-base electrolytic titrations method for the determination of adefovir dipivoxil raw material, and investigate the infulents of the proportion of acetic anhydride in the acetric anhydride and anhydro-glacial acetic acid mixed solution. Methods 75% acetric anhydride was selected as the solvent, and 0.1 mol/L perchloric was selected as the standard solution to determine the content of adefovir dipivoxil in raw material. Results It was found that the end point was changed more acuate with the increasing of acetric anhydride proportion in solvent. The average recovery of adefovir dipivoxil raw material was 99.7% and RSD was 0.2%. Conclusion The method was simple, accurate, and is suitable for the quality control of adefovir dipivoxil raw material.