Prospective study on moxifloxacin in treatment of acute exacerbations of chronic bronchitis (AECB)

Key words: 
• acute exacerbations of chronic bronchitis /
• moxifloxacin /
• clarithromycin

Abstract: Objective To study the effect of moxifloxacin in patients with AECB.Methods 143 patients with AECB were divided into two groups with randomization.The first group took moxifloxacin 400mg×6 days po (per os), and the second group took clarithro-mycin 500mg×6 days po.The clinical effect, the clearance state of bacteria and the adverse reactions were observed.Results The total clinical effective rate was 93.1%,87.9% with the group of moxifloxacin and clarithromycin respectively, there was no significant difference(P<0.05), the absorptivity of infection around bronchia was 84.7%, 71.2% respectively, there was significant difference (P<0.05 ), the clearance of pathogenic bacteria in sputum was 88.9%, 72.1 % respectively, there was significant difference (P<0.05), the occurrence rate of adverse reactions was 1.4%,13.6% respectively, there was significant difference (P<0.05).Conclutions:The clinical effect was almost similar between moxifloxacin and clarithromycin, while, the absorption state of infection around bronchia of moxifloxacin was better than clarithromycin, and had much higher in the clearance of pathogenic bacterium in sputum, also, moxifloxacin has better compliance and tolerance.