Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

XIONG Feng-ying, WU Min, WU Hong-wen, CHEN Guo-ping, GUO Xin-fu. Preparation and quality control of diethylstilbestrol ointment[J]. Journal of Pharmaceutical Practice and Service, 2005, (2): 88-90.
Citation: XIONG Feng-ying, WU Min, WU Hong-wen, CHEN Guo-ping, GUO Xin-fu. Preparation and quality control of diethylstilbestrol ointment[J]. Journal of Pharmaceutical Practice and Service, 2005, (2): 88-90.

Preparation and quality control of diethylstilbestrol ointment

  • Received Date: 2004-09-21
  • Objective To prepare diethylstilbestrol ointment and establish its method of quality control. Methods The diethylstil-bestrol ointment was prepared according to prescription. The HPLC was used to detect the content at 240nm with carbamazepine as the internal standard,and C18 was used as chromatography column while methanol-water(6:4) as mobile phase. Results The ratio of chromatographic peak area of diethylstilbestrol and internal standard correlated linearly with the concentration ranging from 8.0 -32.0μg/mL(r=9999). The average recovery was 98.9% and RSD was 0.33%. Conclusion The preparation technique was practical and the determination of content was credible, and can be utilized in hospital preparation and quality control.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2255) PDF downloads(609) Cited by()

Related
Proportional views

Preparation and quality control of diethylstilbestrol ointment

Abstract: Objective To prepare diethylstilbestrol ointment and establish its method of quality control. Methods The diethylstil-bestrol ointment was prepared according to prescription. The HPLC was used to detect the content at 240nm with carbamazepine as the internal standard,and C18 was used as chromatography column while methanol-water(6:4) as mobile phase. Results The ratio of chromatographic peak area of diethylstilbestrol and internal standard correlated linearly with the concentration ranging from 8.0 -32.0μg/mL(r=9999). The average recovery was 98.9% and RSD was 0.33%. Conclusion The preparation technique was practical and the determination of content was credible, and can be utilized in hospital preparation and quality control.

XIONG Feng-ying, WU Min, WU Hong-wen, CHEN Guo-ping, GUO Xin-fu. Preparation and quality control of diethylstilbestrol ointment[J]. Journal of Pharmaceutical Practice and Service, 2005, (2): 88-90.
Citation: XIONG Feng-ying, WU Min, WU Hong-wen, CHEN Guo-ping, GUO Xin-fu. Preparation and quality control of diethylstilbestrol ointment[J]. Journal of Pharmaceutical Practice and Service, 2005, (2): 88-90.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return