Comparing the shape, diameter and microencapsulation rate of the microcap sules produced by single coacervation and by complex coacervation

Key words: 
• microcapsules /
• single coacervation /
• complex coacervation /
• ketoconazole

Abstract: Objective To compare the microcapsules produced by single coacervation with that produced by complex coacervation, to sure which method was better.Methods Using ketoconazole as core, and the gelatin-acacia gum as the sealing material, microcapsules were produced by single coacervation and complex coacervation respectively.Their shape and diameter were observed under the microscope, and the concentration of ketoconazole was measured by UV spectrophotomelry, their microencapsulating rates were also determinated.Results Microcapsules were white powder either produced by single coacervation or complex one.The diameter and microencapsulating rate of microcapsules produced by single coacerva tion were 32.20μm and 56.11% respectively, while 7.99μm and 83.42% were detected among the microcapsules produced by complex coacervation.Conclusion When microcapsules are prepared by the phase separation-coacervation, the complex coacervation is better.