Preparation and enhancement effect of ketoconazole transfersomes on transder-mal absorption

Key words: 
• ketoconazole /
• transfersomes /
• determination /
• percutaneous absorption /
• transdermal enhancer

Abstract: Objective To prepare and determinate the ketoconazole(KCZ)transfersomes(TF),and to study the enhancing effect on the transdermal absorption of ketoconazole transfersomes.Methods The rotary evaporation method was used for preparation of KCZ TF.The HPLC was employed in its determination.The excised rabbit skin was used as the percutaneous barrier, and the modified franz-diffusion cells were used in the test.The enhancement effect of common nano-liposome, transfersomes, 3% dipentene and 3% azone were compared in the transdermal absorption of ketoconazole.Results The KCZ TF were prepared.The sequence of enhancement at difference transdermal enhancer are follows: transfersomes > 3% dipentene > 3% azone > common nana-liposome.Conclusion It was showed that various transder enhancers could promote absorption of ketoconazole in different degrees and transfersomes was the most effective.