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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2005  >  (4): @-@

CAI Shao-hua, LONG Dong-Ian, CAI Tao-yi. Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases[J]. Journal of Pharmaceutical Practice and Service, 2005, (4): @-@.
Citation: CAI Shao-hua, LONG Dong-Ian, CAI Tao-yi. Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases[J]. Journal of Pharmaceutical Practice and Service, 2005, (4): @-@.
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Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases

  • Department of Pediatrics, No. 175 Hospital of PLA, Zhangzhou 363000, China

  • Received Date: 2005-06-22
  • Objective The results of serum concentration monitoring of 4 antiepileptic drugs with 357 measurements in 164 epilepsy children were evaluated in order to guide clinical rational administration of these antiepileptic drugs.Methods The serum concentration of antiepileptic drugs sodium valproate (VPA), carbamazepine (CBZ),sodium phenytoin (PHT) and phenobarbital (PB) were monitored by HPLC.Results The rate of serum concentrations which were in theraputic window is 47.1%,and which were lower and higher Than theraputic window are 45.9% and 7.0% respectively.The serum concentrations in normal range are founded in only 49.8% of all patients by routine administration, and deviate from normal range by 76.2% in combination with other drugs.Conclusion Serum concentration monitor is an important basis for the treatment of children's epilepsies with antiepileptic drugs, especially in combination with other drugs.
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Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases

  • Department of Pediatrics, No. 175 Hospital of PLA, Zhangzhou 363000, China
  • Received Date: 2005-06-22

Abstract: Objective The results of serum concentration monitoring of 4 antiepileptic drugs with 357 measurements in 164 epilepsy children were evaluated in order to guide clinical rational administration of these antiepileptic drugs.Methods The serum concentration of antiepileptic drugs sodium valproate (VPA), carbamazepine (CBZ),sodium phenytoin (PHT) and phenobarbital (PB) were monitored by HPLC.Results The rate of serum concentrations which were in theraputic window is 47.1%,and which were lower and higher Than theraputic window are 45.9% and 7.0% respectively.The serum concentrations in normal range are founded in only 49.8% of all patients by routine administration, and deviate from normal range by 76.2% in combination with other drugs.Conclusion Serum concentration monitor is an important basis for the treatment of children's epilepsies with antiepileptic drugs, especially in combination with other drugs.

CAI Shao-hua, LONG Dong-Ian, CAI Tao-yi. Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases[J]. Journal of Pharmaceutical Practice and Service, 2005, (4): @-@.
Citation: CAI Shao-hua, LONG Dong-Ian, CAI Tao-yi. Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases[J]. Journal of Pharmaceutical Practice and Service, 2005, (4): @-@.
shu

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