Research on preparation of aripiprazole
- Received Date: 2005-07-05
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Key words:
- aripiprazole /
- preparation
Abstract: Objective To optimize the preparation procedure of aripiprazole. Methods 7-hydroxy-3,4-dihydro-2(1H)-quinolin-one was used as starting material and etherified with 1,4-dibromobutane, then alkylated with 1-(2,3-dichlorophenyl) piperazine to yield the target compound aripiprazole. Results The DMF was replaced by acetone as solvent when etherification. The extraction purification method in the last step was replaced by washing precipitates with water. Aripiprazole was prepared in overall yield of 71. 3%. Conclusion The optimal preparation procedure is stable and available for industrial production.
Citation: | XU Jian-ming, WU Qiu-ye, SUN Qing-yan, ZHANG Jun, YU Shi-chong. Research on preparation of aripiprazole[J]. Journal of Pharmaceutical Practice and Service, 2005, (5): 269-270. |