Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 24 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (1): 20-22

ZHUANG Dong-ping, Wang Shuo-feng, ZHANG Yue-fan, GUI Min, ZHANG Min, ZHANG Jun-ping. Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 20-22.
Citation: ZHUANG Dong-ping, Wang Shuo-feng, ZHANG Yue-fan, GUI Min, ZHANG Min, ZHANG Jun-ping. Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 20-22.
shu

Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages

  • 1.

    Department of Pharmacy, Huian People Hospital, Huian 362100, China

  • 2.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2005-09-05
  • Objective :To study the effect of silybin on fibrogenic cytokines production by mouse peritoneal macrophages. Methods :Mouse peritoneal macrophages were primed with calcimycin 10-6 mol/L for 8 h then elicited by lipopolysa(?)harides (LPS) 100 mg/L for 6 h to induce fibrogenic cytokines.Collagen stimulating activities and transforming growth factor β (TGFβ) activities in the macrophage culture supernatants were assessed by [3H]-proline incorporation assay using rat hepatic stellate HSC-T6 cell and [3H]-thymidine incorporation assay using Mv-1-Lu mink lung epithelial cell respectively. Results :Silybin(6.25-50(μg/mL) inhibited LPS-induced collagen stimulating activities and TGFμ production in a concentration dependent manner. Conclusion :Hepatoprotective and an(?)ifibrotic properties of silibin may partly arise from its actions on fibrogenic cytokines production.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2404) PDF downloads(476) Cited by()

Related
Proportional views

Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages

  • 1. Department of Pharmacy, Huian People Hospital, Huian 362100, China
  • 2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2005-09-05

Abstract: Objective :To study the effect of silybin on fibrogenic cytokines production by mouse peritoneal macrophages. Methods :Mouse peritoneal macrophages were primed with calcimycin 10-6 mol/L for 8 h then elicited by lipopolysa(?)harides (LPS) 100 mg/L for 6 h to induce fibrogenic cytokines.Collagen stimulating activities and transforming growth factor β (TGFβ) activities in the macrophage culture supernatants were assessed by [3H]-proline incorporation assay using rat hepatic stellate HSC-T6 cell and [3H]-thymidine incorporation assay using Mv-1-Lu mink lung epithelial cell respectively. Results :Silybin(6.25-50(μg/mL) inhibited LPS-induced collagen stimulating activities and TGFμ production in a concentration dependent manner. Conclusion :Hepatoprotective and an(?)ifibrotic properties of silibin may partly arise from its actions on fibrogenic cytokines production.

ZHUANG Dong-ping, Wang Shuo-feng, ZHANG Yue-fan, GUI Min, ZHANG Min, ZHANG Jun-ping. Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 20-22.
Citation: ZHUANG Dong-ping, Wang Shuo-feng, ZHANG Yue-fan, GUI Min, ZHANG Min, ZHANG Jun-ping. Effect of silybin on the fibrogenic cytokines production by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 20-22.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return