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Volume 24 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (1): 25-27

YUE Chang-lin, GUO Zhong. Quantitative determination of content in Busulfan's tablets by HPLC-ELSD[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 25-27.
Citation: YUE Chang-lin, GUO Zhong. Quantitative determination of content in Busulfan's tablets by HPLC-ELSD[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 25-27.
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Quantitative determination of content in Busulfan's tablets by HPLC-ELSD

  • 1.

    Zhejiang Jiuxu Pharmaceutical co. , Ltd., Jinhua 321016, China

  • 2.

    Zhejiang Jiukang Pharmaceutical co. , Ltd., Pujiang 322200, China

  • Received Date: 2005-07-08
  • Objective :To establish a HPLC-ELSD method for determining the content of busulfan in busulfan tablets. Methods : The chromatographic conditions were as follows:SHIMADZU C8 column(250mm×4.6mm,5μm),the mobile phase:water-acetonitrile (75-25),the flow rate:1.0mL/min,and the detector:ELSD,the carrier gas:nitrogen,the flow rate:2.0 bar. Results :The standard curve of busulfan was linear over the rage of 0. 25-0.75mg/mL(r=0.9999).The average recovery was 99.7%. Conclusion :This method is accurate and specificity,and it can be used on the quality control of busulfan tablets.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Quantitative determination of content in Busulfan's tablets by HPLC-ELSD

  • 1. Zhejiang Jiuxu Pharmaceutical co. , Ltd., Jinhua 321016, China
  • 2. Zhejiang Jiukang Pharmaceutical co. , Ltd., Pujiang 322200, China
  • Received Date: 2005-07-08

Abstract: Objective :To establish a HPLC-ELSD method for determining the content of busulfan in busulfan tablets. Methods : The chromatographic conditions were as follows:SHIMADZU C8 column(250mm×4.6mm,5μm),the mobile phase:water-acetonitrile (75-25),the flow rate:1.0mL/min,and the detector:ELSD,the carrier gas:nitrogen,the flow rate:2.0 bar. Results :The standard curve of busulfan was linear over the rage of 0. 25-0.75mg/mL(r=0.9999).The average recovery was 99.7%. Conclusion :This method is accurate and specificity,and it can be used on the quality control of busulfan tablets.

YUE Chang-lin, GUO Zhong. Quantitative determination of content in Busulfan's tablets by HPLC-ELSD[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 25-27.
Citation: YUE Chang-lin, GUO Zhong. Quantitative determination of content in Busulfan's tablets by HPLC-ELSD[J]. Journal of Pharmaceutical Practice and Service, 2006, (1): 25-27.
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