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Volume 24 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (3): 144-146

LIU Xin-Yu, WU Fang. The pharmacokinetics study of cefprozil in patients with low respiratory tract bacterial infections[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 144-146.
Citation: LIU Xin-Yu, WU Fang. The pharmacokinetics study of cefprozil in patients with low respiratory tract bacterial infections[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 144-146.
shu

The pharmacokinetics study of cefprozil in patients with low respiratory tract bacterial infections

  • Futian Hospital of Guangdong Medical College, Shenzhen 518033, China

  • Received Date: 2006-04-15
  • Objective :To offer the evidence for reasonable dosage regimen by the pharmacokinetics study of cefprozil in patients with low respiratory tract bacterial infections. Methods :The cefprozil concentration in plasma was determined by the high performance liquid chromatography method. The pharmacokinetic parameters were obtained by using 3P97 imitate program. Results :With oral multiple - dose of 500mg of cefprozil twice over 5 consecutive days, the main pharmacokinetic parameters obtained from the patients were as follows :t1/2 was (1.55±0.17)h,MRT was (2.52 ±0. 15)h.Cmax was ( 13.32 ± 1. 28)μg/mL,tmax was (1.41±0.31)h,AUC0-10 was (31.68 ±7.68)μg·h/mL. Conclusions :Cefprozil 500mg, bid orally may be effective against low respiratory tract bacterial infections.
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The pharmacokinetics study of cefprozil in patients with low respiratory tract bacterial infections

  • Futian Hospital of Guangdong Medical College, Shenzhen 518033, China
  • Received Date: 2006-04-15

Abstract: Objective :To offer the evidence for reasonable dosage regimen by the pharmacokinetics study of cefprozil in patients with low respiratory tract bacterial infections. Methods :The cefprozil concentration in plasma was determined by the high performance liquid chromatography method. The pharmacokinetic parameters were obtained by using 3P97 imitate program. Results :With oral multiple - dose of 500mg of cefprozil twice over 5 consecutive days, the main pharmacokinetic parameters obtained from the patients were as follows :t1/2 was (1.55±0.17)h,MRT was (2.52 ±0. 15)h.Cmax was ( 13.32 ± 1. 28)μg/mL,tmax was (1.41±0.31)h,AUC0-10 was (31.68 ±7.68)μg·h/mL. Conclusions :Cefprozil 500mg, bid orally may be effective against low respiratory tract bacterial infections.

LIU Xin-Yu, WU Fang. The pharmacokinetics study of cefprozil in patients with low respiratory tract bacterial infections[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 144-146.
Citation: LIU Xin-Yu, WU Fang. The pharmacokinetics study of cefprozil in patients with low respiratory tract bacterial infections[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 144-146.
shu

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