Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 24 Issue 3
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (3): 147-149

LU Zhen-dong, Zhang Ge. Inhibitory effects of matrine on the production of matrix metallo - proteinases of human gastric carcinoma cell line MKN - 45[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 147-149.
Citation: LU Zhen-dong, Zhang Ge. Inhibitory effects of matrine on the production of matrix metallo - proteinases of human gastric carcinoma cell line MKN - 45[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 147-149.
shu

Inhibitory effects of matrine on the production of matrix metallo - proteinases of human gastric carcinoma cell line MKN - 45

  • 1.

    Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China

  • 2.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China.

  • Received Date: 2006-01-15
  • Objective : To explore the mechanism of therapeutic effect of matrine on human gastric carcinoma by inhibiting the production of matrix metallo-proleinases of cell line MKN - 45 induced by it. Methods : The production of matrix metalloproteinases (MMP -2,MMP -9)of MKN -45 cells were measured by ELISA and gelatin zymogrmn. Results : In the dose of 5 -20μmol/L, matrine can significantly inhibit MMP-2 as well as MMP-9 expressions in MKN -45 cells. Especially, in the zymographic analysis of MMPs pxressions in conditional culture media, matrine 20μmol/L can greatly inhibit the MMP -2 and MMP -9 enzyme activity. Conclusion : Matrine could significantly inhibit the production and activity of MMPs in gastric carcinoma cell line MKN -45, which showed the inhibitory effect on the metastasis of gastric carcinoma cells.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2287) PDF downloads(187) Cited by()

Related
Proportional views

Inhibitory effects of matrine on the production of matrix metallo - proteinases of human gastric carcinoma cell line MKN - 45

  • 1. Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
  • 2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Received Date: 2006-01-15

Abstract: Objective : To explore the mechanism of therapeutic effect of matrine on human gastric carcinoma by inhibiting the production of matrix metallo-proleinases of cell line MKN - 45 induced by it. Methods : The production of matrix metalloproteinases (MMP -2,MMP -9)of MKN -45 cells were measured by ELISA and gelatin zymogrmn. Results : In the dose of 5 -20μmol/L, matrine can significantly inhibit MMP-2 as well as MMP-9 expressions in MKN -45 cells. Especially, in the zymographic analysis of MMPs pxressions in conditional culture media, matrine 20μmol/L can greatly inhibit the MMP -2 and MMP -9 enzyme activity. Conclusion : Matrine could significantly inhibit the production and activity of MMPs in gastric carcinoma cell line MKN -45, which showed the inhibitory effect on the metastasis of gastric carcinoma cells.

LU Zhen-dong, Zhang Ge. Inhibitory effects of matrine on the production of matrix metallo - proteinases of human gastric carcinoma cell line MKN - 45[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 147-149.
Citation: LU Zhen-dong, Zhang Ge. Inhibitory effects of matrine on the production of matrix metallo - proteinases of human gastric carcinoma cell line MKN - 45[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 147-149.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return