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ZHANG Bei-jing. Studies on the formulation and dissolution in vitro of trifluoperazine hydrochloride oral disintegrating tablets[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 153-155,166.
Citation: ZHANG Bei-jing. Studies on the formulation and dissolution in vitro of trifluoperazine hydrochloride oral disintegrating tablets[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 153-155,166.

Studies on the formulation and dissolution in vitro of trifluoperazine hydrochloride oral disintegrating tablets

  • Received Date: 2006-01-17
  • Objective :To optimize the formulation of the oral disintegrating tablets of trifluoperazine hydrochloride and compare its dissolution profiles with the marketing tablets. Methods : Orthogonal design was used to optimize the formulation of the tablets. The basket method was used to evaluate the dissolution profiles of the tablets. The content of trifluoperazine hydrochloride in the samples was analyzed by UV. Results : When the ratio of gelatia/mannitol/aspartame/trifluoperazine hydrochloride was 0. 15/1/0. 05/0. 16, the tablets has good mouth feel. When the content of crospovidone, L-HPC and microcrystalline cellulose were set at 8%, 5% and 30%, respectively, the disintegration time was within 15s. The cumulative dissolution of the tablets was more than 90% within 5 minute, respectively. Conclusion : The oral disintegrating tablets of trifluoperazine hydrochloride had the advantage of easy administratio-nand its dissolution was significantly higher than that of the market tablets.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Studies on the formulation and dissolution in vitro of trifluoperazine hydrochloride oral disintegrating tablets

Abstract: Objective :To optimize the formulation of the oral disintegrating tablets of trifluoperazine hydrochloride and compare its dissolution profiles with the marketing tablets. Methods : Orthogonal design was used to optimize the formulation of the tablets. The basket method was used to evaluate the dissolution profiles of the tablets. The content of trifluoperazine hydrochloride in the samples was analyzed by UV. Results : When the ratio of gelatia/mannitol/aspartame/trifluoperazine hydrochloride was 0. 15/1/0. 05/0. 16, the tablets has good mouth feel. When the content of crospovidone, L-HPC and microcrystalline cellulose were set at 8%, 5% and 30%, respectively, the disintegration time was within 15s. The cumulative dissolution of the tablets was more than 90% within 5 minute, respectively. Conclusion : The oral disintegrating tablets of trifluoperazine hydrochloride had the advantage of easy administratio-nand its dissolution was significantly higher than that of the market tablets.

ZHANG Bei-jing. Studies on the formulation and dissolution in vitro of trifluoperazine hydrochloride oral disintegrating tablets[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 153-155,166.
Citation: ZHANG Bei-jing. Studies on the formulation and dissolution in vitro of trifluoperazine hydrochloride oral disintegrating tablets[J]. Journal of Pharmaceutical Practice and Service, 2006, (3): 153-155,166.

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