Antinociceptive effects of total Ervatamia yunnansis alkaloid in mice
- Received Date: 2006-01-16
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Key words:
- total Ervatamia yunnansis alkaloid /
- analgesia /
- mice
Abstract: Objective: To observe the antinoeiceptive effect of total Ervatamia yunnansis alkaloid(TEYA) in mice. Methods: The mice hot-plate antinociceptve test was used to study the analgesic effects of TEYA and the effect on morphine in mice. Results: The three groups with different dosage of TEYA could significantly increase the pain threshold in mice and the effects increased in a dose-related manner. TEYA(10、20 mg/kg) combined with morphine 4 mg/kg had a synergic analgesic effect. The analgesic effect of TEYA could he partly blocked by naloxone 4 mg/kg. There were significantly differences between administration group and control group in the hot-plate test. Conclusion: TEYA has significant antinoeiceptive activity in hot-plate lest in mice which may be mediated by way of opioid receptors.
Citation: | CHEN Mei-yu, ZHOU Li-hua, ZHANG Xiao-dong, LUO Xin-gen, CHEN Hai-sheng, HUANG Mao. Antinociceptive effects of total Ervatamia yunnansis alkaloid in mice[J]. Journal of Pharmaceutical Practice and Service, 2006, (4): 203-205. |