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CHEN Mei-yu, ZHOU Li-hua, ZHANG Xiao-dong, LUO Xin-gen, CHEN Hai-sheng, HUANG Mao. Antinociceptive effects of total Ervatamia yunnansis alkaloid in mice[J]. Journal of Pharmaceutical Practice and Service, 2006, (4): 203-205.
Citation: CHEN Mei-yu, ZHOU Li-hua, ZHANG Xiao-dong, LUO Xin-gen, CHEN Hai-sheng, HUANG Mao. Antinociceptive effects of total Ervatamia yunnansis alkaloid in mice[J]. Journal of Pharmaceutical Practice and Service, 2006, (4): 203-205.

Antinociceptive effects of total Ervatamia yunnansis alkaloid in mice

  • Received Date: 2006-01-16
  • Objective: To observe the antinoeiceptive effect of total Ervatamia yunnansis alkaloid(TEYA) in mice. Methods: The mice hot-plate antinociceptve test was used to study the analgesic effects of TEYA and the effect on morphine in mice. Results: The three groups with different dosage of TEYA could significantly increase the pain threshold in mice and the effects increased in a dose-related manner. TEYA(10、20 mg/kg) combined with morphine 4 mg/kg had a synergic analgesic effect. The analgesic effect of TEYA could he partly blocked by naloxone 4 mg/kg. There were significantly differences between administration group and control group in the hot-plate test. Conclusion: TEYA has significant antinoeiceptive activity in hot-plate lest in mice which may be mediated by way of opioid receptors.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Antinociceptive effects of total Ervatamia yunnansis alkaloid in mice

Abstract: Objective: To observe the antinoeiceptive effect of total Ervatamia yunnansis alkaloid(TEYA) in mice. Methods: The mice hot-plate antinociceptve test was used to study the analgesic effects of TEYA and the effect on morphine in mice. Results: The three groups with different dosage of TEYA could significantly increase the pain threshold in mice and the effects increased in a dose-related manner. TEYA(10、20 mg/kg) combined with morphine 4 mg/kg had a synergic analgesic effect. The analgesic effect of TEYA could he partly blocked by naloxone 4 mg/kg. There were significantly differences between administration group and control group in the hot-plate test. Conclusion: TEYA has significant antinoeiceptive activity in hot-plate lest in mice which may be mediated by way of opioid receptors.

CHEN Mei-yu, ZHOU Li-hua, ZHANG Xiao-dong, LUO Xin-gen, CHEN Hai-sheng, HUANG Mao. Antinociceptive effects of total Ervatamia yunnansis alkaloid in mice[J]. Journal of Pharmaceutical Practice and Service, 2006, (4): 203-205.
Citation: CHEN Mei-yu, ZHOU Li-hua, ZHANG Xiao-dong, LUO Xin-gen, CHEN Hai-sheng, HUANG Mao. Antinociceptive effects of total Ervatamia yunnansis alkaloid in mice[J]. Journal of Pharmaceutical Practice and Service, 2006, (4): 203-205.

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