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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (3): 143-144,149

REN Tian-shu, LI Lin-peng, JIANG Yuan-ying. Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 143-144,149.
Citation: REN Tian-shu, LI Lin-peng, JIANG Yuan-ying. Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 143-144,149.
shu

Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats

  • 1.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; Department of Pharmacy, the General Hospital of Shenyang Military Command,Shenyang 110016, China

  • 2.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2006-10-23
  • Objective:To study the LDL oxidation in hypercholesteremia rats and the effects of atorvastatin.Methods:The experimental model of hypercholesteremia was established in rats by ig. fat emulsion. 30 wistar rats were sub-divided randomly into the control group、the model group and the atorvastatin group(5 mg/kg·d). After 4 weeks, the serum TC、LDL-c、HDL-c、SOD、MDA、ox-LDL were detected by enzyme or ELISA methods. In addition, (TC-HDL-c)/HDL-c and LDL-c/HDL-c were calculated. Results:Contrast with control group, LDL、LDL-c、(TC-HDL-c)/HDL-c、LDL-c/HDL-c、ox-LDL、MDA were markedly higher, while HDL-c and SOD were markedly lower in model group (P<0. 01). LDL、LDL-c、(TC-HDL-c)/HDL-c、 LDL-c/HDL-c、ox-LDL、MDA were markedly lower in ATV group than that in model group(P<0. 01); HDL-c and SOD were significantly higher in ATV group than that in model group(P<0. 01). Conclusion:Atorvastatin decreased blood lipid, inhibited the lipid peroxidation and the oxidative modification of LDL of rat serum. This result may be one of mechanisms in preventing atherosclerosis.
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Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats

  • 1. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; Department of Pharmacy, the General Hospital of Shenyang Military Command,Shenyang 110016, China
  • 2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2006-10-23

Abstract: Objective:To study the LDL oxidation in hypercholesteremia rats and the effects of atorvastatin.Methods:The experimental model of hypercholesteremia was established in rats by ig. fat emulsion. 30 wistar rats were sub-divided randomly into the control group、the model group and the atorvastatin group(5 mg/kg·d). After 4 weeks, the serum TC、LDL-c、HDL-c、SOD、MDA、ox-LDL were detected by enzyme or ELISA methods. In addition, (TC-HDL-c)/HDL-c and LDL-c/HDL-c were calculated. Results:Contrast with control group, LDL、LDL-c、(TC-HDL-c)/HDL-c、LDL-c/HDL-c、ox-LDL、MDA were markedly higher, while HDL-c and SOD were markedly lower in model group (P<0. 01). LDL、LDL-c、(TC-HDL-c)/HDL-c、 LDL-c/HDL-c、ox-LDL、MDA were markedly lower in ATV group than that in model group(P<0. 01); HDL-c and SOD were significantly higher in ATV group than that in model group(P<0. 01). Conclusion:Atorvastatin decreased blood lipid, inhibited the lipid peroxidation and the oxidative modification of LDL of rat serum. This result may be one of mechanisms in preventing atherosclerosis.

REN Tian-shu, LI Lin-peng, JIANG Yuan-ying. Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 143-144,149.
Citation: REN Tian-shu, LI Lin-peng, JIANG Yuan-ying. Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 143-144,149.
shu

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