Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 25 Issue 3
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (3): 143-144,149

REN Tian-shu, LI Lin-peng, JIANG Yuan-ying. Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 143-144,149.
Citation: REN Tian-shu, LI Lin-peng, JIANG Yuan-ying. Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 143-144,149.
shu

Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats

  • 1.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; Department of Pharmacy, the General Hospital of Shenyang Military Command,Shenyang 110016, China

  • 2.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2006-10-23
  • Objective:To study the LDL oxidation in hypercholesteremia rats and the effects of atorvastatin.Methods:The experimental model of hypercholesteremia was established in rats by ig. fat emulsion. 30 wistar rats were sub-divided randomly into the control group、the model group and the atorvastatin group(5 mg/kg·d). After 4 weeks, the serum TC、LDL-c、HDL-c、SOD、MDA、ox-LDL were detected by enzyme or ELISA methods. In addition, (TC-HDL-c)/HDL-c and LDL-c/HDL-c were calculated. Results:Contrast with control group, LDL、LDL-c、(TC-HDL-c)/HDL-c、LDL-c/HDL-c、ox-LDL、MDA were markedly higher, while HDL-c and SOD were markedly lower in model group (P<0. 01). LDL、LDL-c、(TC-HDL-c)/HDL-c、 LDL-c/HDL-c、ox-LDL、MDA were markedly lower in ATV group than that in model group(P<0. 01); HDL-c and SOD were significantly higher in ATV group than that in model group(P<0. 01). Conclusion:Atorvastatin decreased blood lipid, inhibited the lipid peroxidation and the oxidative modification of LDL of rat serum. This result may be one of mechanisms in preventing atherosclerosis.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2003) PDF downloads(560) Cited by()

Related
Proportional views

Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats

  • 1. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; Department of Pharmacy, the General Hospital of Shenyang Military Command,Shenyang 110016, China
  • 2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2006-10-23

Abstract: Objective:To study the LDL oxidation in hypercholesteremia rats and the effects of atorvastatin.Methods:The experimental model of hypercholesteremia was established in rats by ig. fat emulsion. 30 wistar rats were sub-divided randomly into the control group、the model group and the atorvastatin group(5 mg/kg·d). After 4 weeks, the serum TC、LDL-c、HDL-c、SOD、MDA、ox-LDL were detected by enzyme or ELISA methods. In addition, (TC-HDL-c)/HDL-c and LDL-c/HDL-c were calculated. Results:Contrast with control group, LDL、LDL-c、(TC-HDL-c)/HDL-c、LDL-c/HDL-c、ox-LDL、MDA were markedly higher, while HDL-c and SOD were markedly lower in model group (P<0. 01). LDL、LDL-c、(TC-HDL-c)/HDL-c、 LDL-c/HDL-c、ox-LDL、MDA were markedly lower in ATV group than that in model group(P<0. 01); HDL-c and SOD were significantly higher in ATV group than that in model group(P<0. 01). Conclusion:Atorvastatin decreased blood lipid, inhibited the lipid peroxidation and the oxidative modification of LDL of rat serum. This result may be one of mechanisms in preventing atherosclerosis.

REN Tian-shu, LI Lin-peng, JIANG Yuan-ying. Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 143-144,149.
Citation: REN Tian-shu, LI Lin-peng, JIANG Yuan-ying. Free radical metabolic disorder and intervention of atorvastatin on hypercholesteremia rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 143-144,149.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return