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Volume 25 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (3): 147-149

LIU Run-hui, CHEN Zhong-liang, LI Tie-jun, LIU Xiao-hua, XU Rui-lin, XU Xi-ke, ZHANG Chuan, ZHANG Wei-dong. The protective effects of Danning tablet on experimental liver injury in mice and rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 147-149.
Citation: LIU Run-hui, CHEN Zhong-liang, LI Tie-jun, LIU Xiao-hua, XU Rui-lin, XU Xi-ke, ZHANG Chuan, ZHANG Wei-dong. The protective effects of Danning tablet on experimental liver injury in mice and rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 147-149.
shu

The protective effects of Danning tablet on experimental liver injury in mice and rats

  • 1.

    Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, China;

  • 2.

    Shanghai Hehuang Pharmaceutical Company Limited, Shanghai 200331,China;

  • 3.

    Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2006-04-17
  • Objective:To study the protective effects of Danning tablet on CCl4 and D-galactosamine induced liver injury in mice and rats.Methods:Mice and rats were induced acute and chronic liver injury by administrated with D-galactosamine and CCl4 respectively,and the activities of glutamic-oxal(o)acetic transaminase(AST) and glutamate-pyruvate transaminase(ALT) in plasma were detected,influence on contents of the serum total protein,albumin and A/G were observed, histopathologic examination was employed to observe the liver injury. Results:Danning tablet can significantly inhibited the activities of ALT and AST which were rised by CCl4 and D-galactosamine(P<0.05 or P<0.01),can significantly increased the contents of the total protein, albumin which were decreased by CCl4(P<0.05 or P<0.01),Histopathologic examination show degree of fatty degeneration and fibrosis of liver cell were improved by Danning tablet.Conclusion: Danning tablet are effective in liver injuries induced by CCl4 and D-galactosamine.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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The protective effects of Danning tablet on experimental liver injury in mice and rats

  • 1. Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, China;
  • 2. Shanghai Hehuang Pharmaceutical Company Limited, Shanghai 200331,China;
  • 3. Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2006-04-17

Abstract: Objective:To study the protective effects of Danning tablet on CCl4 and D-galactosamine induced liver injury in mice and rats.Methods:Mice and rats were induced acute and chronic liver injury by administrated with D-galactosamine and CCl4 respectively,and the activities of glutamic-oxal(o)acetic transaminase(AST) and glutamate-pyruvate transaminase(ALT) in plasma were detected,influence on contents of the serum total protein,albumin and A/G were observed, histopathologic examination was employed to observe the liver injury. Results:Danning tablet can significantly inhibited the activities of ALT and AST which were rised by CCl4 and D-galactosamine(P<0.05 or P<0.01),can significantly increased the contents of the total protein, albumin which were decreased by CCl4(P<0.05 or P<0.01),Histopathologic examination show degree of fatty degeneration and fibrosis of liver cell were improved by Danning tablet.Conclusion: Danning tablet are effective in liver injuries induced by CCl4 and D-galactosamine.

LIU Run-hui, CHEN Zhong-liang, LI Tie-jun, LIU Xiao-hua, XU Rui-lin, XU Xi-ke, ZHANG Chuan, ZHANG Wei-dong. The protective effects of Danning tablet on experimental liver injury in mice and rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 147-149.
Citation: LIU Run-hui, CHEN Zhong-liang, LI Tie-jun, LIU Xiao-hua, XU Rui-lin, XU Xi-ke, ZHANG Chuan, ZHANG Wei-dong. The protective effects of Danning tablet on experimental liver injury in mice and rats[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 147-149.
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