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Volume 25 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (3): 154-156

YANG Shi-ting, LUAN Fu-cheng, NI Wei-lei. Effect of pH to the stability of diltiazem hydrochloride for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 154-156.
Citation: YANG Shi-ting, LUAN Fu-cheng, NI Wei-lei. Effect of pH to the stability of diltiazem hydrochloride for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 154-156.
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Effect of pH to the stability of diltiazem hydrochloride for injection

  • Shanghai Industrial United Holdings Pharmaceutical Research Co., Ltd., Shanghai 201707,China

  • Received Date: 2006-07-10
  • Objective:To confirm the preparative technology of diltiazem hydrochloride for injection and the effect factor of stability. Methods:HPLC method was used for the determination of content and related substances of diltiazem hydrochloride, and study of the stability of the preparation at high temperature, high humidity and strong illumination.Results:Optimum pH of diltiazem hydrochloride solution was 4. Optimum pH of diltiazen hydrochloride for injection was 5. Diltiazem hydrochloride for injection was unstable at high temperature and strong illumination. The preparation would dent at high humidity.Conclusions:This preparation procedure can reduce related substances availably and improve the stability of the preparation.
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Effect of pH to the stability of diltiazem hydrochloride for injection

  • Shanghai Industrial United Holdings Pharmaceutical Research Co., Ltd., Shanghai 201707,China
  • Received Date: 2006-07-10

Abstract: Objective:To confirm the preparative technology of diltiazem hydrochloride for injection and the effect factor of stability. Methods:HPLC method was used for the determination of content and related substances of diltiazem hydrochloride, and study of the stability of the preparation at high temperature, high humidity and strong illumination.Results:Optimum pH of diltiazem hydrochloride solution was 4. Optimum pH of diltiazen hydrochloride for injection was 5. Diltiazem hydrochloride for injection was unstable at high temperature and strong illumination. The preparation would dent at high humidity.Conclusions:This preparation procedure can reduce related substances availably and improve the stability of the preparation.

YANG Shi-ting, LUAN Fu-cheng, NI Wei-lei. Effect of pH to the stability of diltiazem hydrochloride for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 154-156.
Citation: YANG Shi-ting, LUAN Fu-cheng, NI Wei-lei. Effect of pH to the stability of diltiazem hydrochloride for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 154-156.
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