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YANG Shi-ting, LUAN Fu-cheng, NI Wei-lei. Effect of pH to the stability of diltiazem hydrochloride for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 154-156.
Citation: YANG Shi-ting, LUAN Fu-cheng, NI Wei-lei. Effect of pH to the stability of diltiazem hydrochloride for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 154-156.

Effect of pH to the stability of diltiazem hydrochloride for injection

  • Received Date: 2006-07-10
  • Objective:To confirm the preparative technology of diltiazem hydrochloride for injection and the effect factor of stability. Methods:HPLC method was used for the determination of content and related substances of diltiazem hydrochloride, and study of the stability of the preparation at high temperature, high humidity and strong illumination.Results:Optimum pH of diltiazem hydrochloride solution was 4. Optimum pH of diltiazen hydrochloride for injection was 5. Diltiazem hydrochloride for injection was unstable at high temperature and strong illumination. The preparation would dent at high humidity.Conclusions:This preparation procedure can reduce related substances availably and improve the stability of the preparation.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effect of pH to the stability of diltiazem hydrochloride for injection

Abstract: Objective:To confirm the preparative technology of diltiazem hydrochloride for injection and the effect factor of stability. Methods:HPLC method was used for the determination of content and related substances of diltiazem hydrochloride, and study of the stability of the preparation at high temperature, high humidity and strong illumination.Results:Optimum pH of diltiazem hydrochloride solution was 4. Optimum pH of diltiazen hydrochloride for injection was 5. Diltiazem hydrochloride for injection was unstable at high temperature and strong illumination. The preparation would dent at high humidity.Conclusions:This preparation procedure can reduce related substances availably and improve the stability of the preparation.

YANG Shi-ting, LUAN Fu-cheng, NI Wei-lei. Effect of pH to the stability of diltiazem hydrochloride for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 154-156.
Citation: YANG Shi-ting, LUAN Fu-cheng, NI Wei-lei. Effect of pH to the stability of diltiazem hydrochloride for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (3): 154-156.

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