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YE Xia. Determination of tolperisone hydrochloride tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 232-234.
Citation: YE Xia. Determination of tolperisone hydrochloride tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 232-234.

Determination of tolperisone hydrochloride tablets by HPLC

  • Received Date: 2007-03-22
  • Objective: To establishe a HPLC method for determination of tolperisone hydrochloride tablets. Methods: A Phenome- nex Luna C~(18) column(250 mm×4.6 mm,5μm)was used,the mobile phases was consisted of acetonitrile-0.1 mol/L sodium acetate (25:75)(adjust pH to 3.5 with acetic acid glacial),the flow rate was 1.2mL/min,the detector wavelength was at 261 nm。 Results: The linear range was 20.2~202.0μg,/mL(r=0.99999),the mean average recovery was 99.9% and RSD was 0.6%。 Conclusion: The method is simple,rapid and accurate.It can be used to quality control the tolperisone hydrochloride tablets.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of tolperisone hydrochloride tablets by HPLC

Abstract: Objective: To establishe a HPLC method for determination of tolperisone hydrochloride tablets. Methods: A Phenome- nex Luna C~(18) column(250 mm×4.6 mm,5μm)was used,the mobile phases was consisted of acetonitrile-0.1 mol/L sodium acetate (25:75)(adjust pH to 3.5 with acetic acid glacial),the flow rate was 1.2mL/min,the detector wavelength was at 261 nm。 Results: The linear range was 20.2~202.0μg,/mL(r=0.99999),the mean average recovery was 99.9% and RSD was 0.6%。 Conclusion: The method is simple,rapid and accurate.It can be used to quality control the tolperisone hydrochloride tablets.

YE Xia. Determination of tolperisone hydrochloride tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 232-234.
Citation: YE Xia. Determination of tolperisone hydrochloride tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2007, (4): 232-234.

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